In Silico Identification and Evolutionary Analysis of Plant MAPKK6s
In Silico Identification and Evolutionary Analysis of Plant MAPKK6s
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植物 MAPKK6 的计算机模拟鉴定和进化分析
DOI：
10.1007/s11105-011-0295-4
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发表时间：
2011-12-01
影响因子：
2.1
通讯作者：
Li, Dequan
中科院分区：
文献类型：
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作者：
Liu, Yukun;Zhou, Yan;Li, Dequan
丝裂原活化蛋白激酶(MAPK)级联通路是植物体内普遍存在的信号转导模块。连接上游MAPK和下游MAPK的MAPK在MAPK信号通路中起着至关重要的作用。MAPKK6是MAPKK家族的成员之一。本研究发现，植物MAPKK6基因广泛分布于苔藓、无核维管植物、裸子植物和被子植物等不同物种中。然而，在藻类基因组中没有发现MAPKK6。外显子-内含子组织和内含子阶段分析表明，植物MAPKK6基因是植物进化过程中高度保守的基因。在小卷柏、卷柏和青云杉中，MAPKK6基因以多拷贝形式存在。然而，在大多数高等植物中，MAPKK6以单拷贝形式存在。系统发育分析表明，高等植物中MAPKK6s的单拷贝可能是由于基因组拷贝数丢失所致。
Mitogen-activated protein kinase (MAPK) cascades are universal signal transduction modules in plants. Linking upstream MAPK kinase kinase (MAPKKK) to downstream MAPK, MAPK kinase (MAPKK) plays a crucial role in MAPK cascade. MAPKK6 is one member of the MAPKK family. In this study, we have found that plant MAPKK6 genes are widely distributed in different plant species, including moss, seedless vascular plants, gymnosperms, and angiosperms. However, no MAPKK6 can be found in genomes of algae. Analysis of exon–intron organization and intron phase showed that plant MAPKK6s are highly conserved genes during plant evolution. In Physcomitrella patens, Selaginella moellendorffii, and Picea glauca, MAPKK6s exist as multicopy genes. In most high plants, however, MAPKK6s exist as single-copy. Phylogenetic analysis indicated that the occurrence of single-copy of MAPKK6s in high plants is likely because of genomic copy-number loss.