Fear of negative evaluation is associated with altered brain function in nonclinical subjects
Fear of negative evaluation is associated with altered brain function in nonclinical subjects
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DOI：
10.1016/j.pscychresns.2015.10.001
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发表时间：
2015-12-30
影响因子：
2.3
通讯作者：
Nomura, Michio
中科院分区：
文献类型：
--
作者：
Kajimura, Shogo;Kochiyama, Takanori;Nomura, Michio
社交焦虑症(SAD)包括过度焦虑和对负面评价的恐惧，并伴有大脑功能异常。虽然社交焦虑似乎表现在从非临床行为到临床表现的一系列疾病上，但非临床人群中的神经变化仍不清楚。本研究考察了社交焦虑的心理测量，主要使用消极评估恐惧量表(FNES)和脑功能(功能连通性、程度中心性和区域中间性中心性)之间的关系。结果显示，FNES评分与海马旁回和眶前叶皮质的功能连接性以及右侧顶叶皮质的中间中心性呈负相关。在SAD患者中，这些区域会发生变化，每个区域都与社会认知和情绪处理有关。研究结果支持了社交焦虑发生在频谱上的观点，并表明FNES是一种检测可能与社交焦虑频谱有关的神经变化的有用手段。此外，研究结果表明，图表分析在研究SAD的神经基础以及其他精神症状方面是有用的。(C)2015爱思唯尔爱尔兰有限公司。保留所有权利。
Social anxiety disorder (SAD), which involves excessive anxiety and fear of negative evaluation, is accompanied by abnormalities in brain function. While social anxiety appears to be represented on a spectrum ranging from nonclinical behavior to clinical manifestation, neural alteration in nonclinical populations remains unclear. This study examined the relationship between psychological measures of social anxiety, mainly using the Fear of Negative Evaluation Scale (FNES), and brain function (functional connectivity, degree centrality, and regional betweenness centrality). Results showed that FNES scores and functional connectivity of the parahippocampal gyrus and orbitofrontal cortex and the betweenness centrality of the right parietal cortex were negatively correlated. These regions are altered in SAD patients, and each is associated with social cognition and emotional processing. The results supported the perspective that social anxiety occurs on a spectrum and indicated that the FNES is a useful means of detecting neural alterations that may relate to the social anxiety spectrum. In addition, the findings indicated that graph analysis was useful in investigating the neural underpinnings of SAD in addition to other psychiatric symptoms. (C) 2015 Elsevier Ireland Ltd. All rights reserved.