Peptides encoded by the calcitonin gene inhibit macrophage function.
Peptides encoded by the calcitonin gene inhibit macrophage function.
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DOI：
10.4049/jimmunol.143.1.45
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发表时间：
1989-07
影响因子：
4.4
通讯作者：
Y. Nong;R. Titus;J. Ribeiro;H. Remold
中科院分区：
文献类型：
--
作者：
Y. Nong;R. Titus;J. Ribeiro;H. Remold
神经肽被认为在许多免疫功能的调节中起着重要作用。降钙素基因相关肽（Calcitonin gene-related peptide， CGRP）是神经肽中的一种，在ifn - γ的作用下，被发现能深刻抑制巨噬细胞产生H2O2的能力或作为APC。为了抑制H2O2的产生，需要用CGRP对巨噬细胞进行预孵育。在大小相似的神经肽中，降钙素也能阻止巨噬细胞的激活，但促肾上腺皮质激素没有。这些发现表明CGRP和降钙素在调节巨噬细胞递呈Ag和对活化因子的反应能力中起重要作用。
Neuropeptides are considered to play an important role in the modulation of a number of immune functions. Calcitonin gene-related peptide (CGRP), one of the neuropeptides, was found to profoundly inhibit the ability of macrophages to produce H2O2 in response to IFN-gamma or to act as APC. For the inhibition of H2O2 production to occur, preincubation of the macrophages with CGRP was required. Among neuropeptides that are similar in size, calcitonin also prevented macrophage activation but adrenocorticotropic hormone did not. These findings suggest that CGRP and calcitonin play an important role in modulating the ability of macrophages to present Ag and to respond to activating factors.