SURFACE-MORPHOLOGY OF THE INNER SULCUS AND RELATED EPITHELIAL-CELLS OF THE COCHLEA FOLLOWING ACOUSTIC TRAUMA
SURFACE-MORPHOLOGY OF THE INNER SULCUS AND RELATED EPITHELIAL-CELLS OF THE COCHLEA FOLLOWING ACOUSTIC TRAUMA
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DOI：
10.1016/0378-5955(84)90004-2
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发表时间：
1984-01-01
期刊：
影响因子：
2.8
通讯作者：
WRIGHT, CG
中科院分区：
文献类型：
--
作者：
HAMERNIK, RP;TURRENTINE, G;WRIGHT, CG
当Corti器官受到强烈（160分贝）冲击波的严重创伤时，多达7毫米的Corti器官从基底膜上被撕裂，内沟细胞对内淋巴生化环境的改变作出反应，通过表面膜的大量发育、卵裂和大量伪足和微绒毛的发育。在纵向研究的基础上，这种表面反应似乎在创伤后大约10天达到高峰，这可能表明内沟细胞在细胞碎片的内吞作用中非常活跃。创伤后，内沟细胞表面立即出现活跃变化的迹象，并且活动在暴露后持续长达30天。克劳迪斯的细胞，以及基底膜上的其他上皮细胞，也具有极强的膜增殖和移动性。讨论了这种异常行为的可能机制以及内沟细胞在正常功能耳蜗中的作用。
When the organ of Corti is severely traumatized by intense (160 dB) blast waves, such that as much as 7 mm of Corti''s organ is torn loose from the basilar membrane, the cells of the inner sulcus respond to the altered biochemical milieu of the endolymph by a prolific elaboration of surface membrane, zeiosis and the development of numerous pseudopodia and microvilli. On the basis of the longitudinal study, this surface reaction appears to peak at approximately 10 days after trauma and may indicate that the inner sulcus cells are extremely active in the endocytosis of cellular debris. Signs of active changes on the surface of the inner sulcus cells occur immediately following trauma, and activity continues for as long as 30 days after exposure. The cells of Claudius, as well as other epithelial cells on the basilar membrane, are also capable of extreme membrane proliferation and mobility. Possible mechanisms for the unusual behavior and the role of the inner sulcus cells in the normal functioning cochlea are discussed.