Costimulation of CD8 T cell responses by OX40
Costimulation of CD8 T cell responses by OX40
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DOI：
10.4049/jimmunol.172.8.4821
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发表时间：
2004-04-15
影响因子：
4.4
通讯作者：
Croft, M
中科院分区：
文献类型：
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作者：
Bansal-Pakala, P;Halteman, BS;Croft, M
功能性CD 8 T细胞应答的持续性取决于在引发期间建立的检查点。虽然初始CD 8细胞可以在短时间的刺激下增殖，但CD 4辅助、炎症和/或高肽亲和力对于CTL的存活和有效的引发是必需的。使用OX 40缺陷的CD 8细胞特异性的一个定义的银，激动剂和拮抗剂OX 40试剂，我们表明，OX 40/OX 40配体的相互作用可以确定CD 8 T细胞的扩展程度在响应传统的蛋白质Ag，并可以提供足够的信号，赋予CTL介导的保护，防止肿瘤生长。OX 40信号传导的主要功能是在Ag相遇后的细胞分裂的最初几轮期间维持CTL存活。因此，OX 40是一种共刺激分子，可以在免疫应答期间提供信号以调节Ag反应性CD 8细胞的积累。
The persistence of functional CD8 T cell responses is dependent on checkpoints established during priming. Although naive CD8 cells can proliferate with a short period of stimulation, CD4 help, inflammation, and/or high peptide affinity are necessary for the survival of CTL and for effective priming. Using OX40-deficient CD8 cells specific for a defined Ag, and agonist and antagonist OX40 reagents, we show that OX40/OX40 ligand interactions can determine the extent of expansion of CD8 T cells during responses to conventional protein Ag and can provide sufficient signals to confer CTL-mediated protection against tumor growth. OX40 signaling primarily functions to maintain CTL survival during the initial rounds of cell division after Ag encounter. Thus, OX40 is one of the costimulatory molecules that can contribute signals to regulate the accumulation of Ag-reactive CD8 cells during immune responses.