CLINICAL AND PATHOLOGICAL FEATURES OF DIFFUSE CORTICAL LEWY BODY DISEASE (LEWY BODY DEMENTIA)
CLINICAL AND PATHOLOGICAL FEATURES OF DIFFUSE CORTICAL LEWY BODY DISEASE (LEWY BODY DEMENTIA)
复制标题
DOI：
10.1093/brain/110.5.1131
复制
发表时间：
1987-10-01
期刊：
影响因子：
14.5
通讯作者：
LEES, AJ
中科院分区：
文献类型：
--
作者：
GIBB, WRG;ESIRI, MM;LEES, AJ
描述了四名患有严重痴呆和帕金森综合征的患者。语言障碍、计算障碍、运动障碍、视觉和言语记忆障碍和精神病，通常为抑郁型，出现在病程早期。病理上表现为遍布大脑皮层和脑干的大量路易小体。3例患者在新皮层也有严重的神经原纤维缠结改变或老年斑，与阿尔茨海默病相符，但皮层缠结分布并不总是与路易小体相符。这种疾病可能构成帕金森病病理谱的一部分，可能是痴呆症的一个可能原因。
Four patients with severe dementia and a parkinsonian syndrome are described. Dysphasia, dyscalculia, dyspraxia, visual and verbal memory disturbance and psychosis, usually of depressive type, occurred early in the course of the illness. Pathologically they were characterized by the presence of numerous Lewy bodies throughout both the cerebral cortex and brainstem. Three cases also had severe neurofibrillary tangle change or senile plaques in the neocortex, compatible with Alzheimer's disease, but the cortical tangle distribution did not always match that of the Lewy bodies. This disorder may form part of the spectrum of pathology in Parkinson's disease, where it may be one possible cause of dementia.