Tumor development under angiogenic signaling: a dynamical theory of tumor growth, treatment response, and postvascular dormancy.
Tumor development under angiogenic signaling: a dynamical theory of tumor growth, treatment response, and postvascular dormancy.
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发表时间：
1999-10
期刊：
影响因子：
11.2
通讯作者：
P. Hahnfeldt;D. Panigrahy;J. Folkman;L. Hlatky
中科院分区：
文献类型：
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作者：
P. Hahnfeldt;D. Panigrahy;J. Folkman;L. Hlatky
血管生成抑制剂内皮抑素，血管抑素，和TNP-470对肿瘤生长动力学的影响进行了实验和理论研究。在这些数据的基础上，我们提出了一个定量的理论，肿瘤生长下的血管生成刺激剂/抑制剂的控制，这是解释和临床上可实施的。我们的分析提供了这些抑制剂的相对有效性的排名。此外，它揭示了在血管生成控制下存在对肿瘤大小的最终限制，其中相反的血管生成刺激进入动态平衡，这可以通过抗血管生成治疗来调节。血管生成驱动的生长和抑制的竞争性影响，这一框架的基础可能有分歧的组织大小调节一般。
The effects of the angiogenic inhibitors endostatin, angiostatin, and TNP-470 on tumor growth dynamics are experimentally and theoretically investigated. On the basis of the data, we pose a quantitative theory for tumor growth under angiogenic stimulator/inhibitor control that is both explanatory and clinically implementable. Our analysis offers a ranking of the relative effectiveness of these inhibitors. Additionally, it reveals the existence of an ultimate limitation to tumor size under angiogenic control, where opposing angiogenic stimuli come into dynamic balance, which can be modulated by antiangiogenic therapy. The competitive influences of angiogenically driven growth and inhibition underlying this framework may have ramifications for tissue size regulation in general.