The Impact of Red Blood Cell Distribution Width and Neutrophil/Lymphocyte Ratio on the Diagnosis of Major Depressive Disorder.
The Impact of Red Blood Cell Distribution Width and Neutrophil/Lymphocyte Ratio on the Diagnosis of Major Depressive Disorder.
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DOI：
10.1007/s40120-015-0039-8
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发表时间：
2016-06
影响因子：
3.7
通讯作者：
Atmaca M
中科院分区：
文献类型：
--
作者：
Demircan F;Gözel N;Kılınç F;Ulu R;Atmaca M
重性抑郁障碍（MDD）是心血管疾病发病率和死亡率的重要危险因素。红细胞分布宽度（RDW）和中性粒细胞/淋巴细胞比率（NLR）可通过基本血象检查获得。这些参数已被发现作为一般人群和心血管疾病等几种疾病死亡率的预测指标。我们的研究包括100名新诊断的MDD患者和100名健康对照患者（没有抑郁症状，也没有心脏病）。MDD患者开始使用选择性5-羟色胺再摄取抑制剂（SSRI）治疗，并随访3个月。在诊断时和治疗3个月后，对MDD和对照组患者进行实验室检查和体格、神经和精神检查。总共评估了100例MDD患者，其中80例纳入我们的研究。对照组由91名健康人组成。MDD患者的平均年龄为44 ± 10.6岁，对照组为39.8 ± 11.4岁。各组之间的年龄无显著差异（P = 0.13）; 55%的MDD患者和33%的对照组患者为男性。MDD患者NLR水平为2.55 ± 0.7，RDW水平为14.3 ± 2.6;对照组NLR水平为1.41 ± 0.8，RDW水平为13.4 ± 1.8。MDD患者的RDW和NLR水平显著高于对照组。经SSRI治疗后，MDD患者RDW和NLR水平与对照组比较差异均消失（P < 0.001）。MDD患者的RDW [中位数14.3，四分位距（IQR）2.8 vs.中位数13.25，IQR 2.45; P < 0.001]和NLR（中位数2.3，IQR 1.1 vs.中位数2.0，IQR 1.15; P < 0.001）水平显著高于对照组。我们的研究表明，血液学炎症标志物可能是可用于MDD患者冠状动脉疾病风险的有用参数。具体来说，RDW和NLR似乎更有希望。需要进行更深入、更详细和更大规模的研究。
Major depressive disorder (MDD) is an important risk factor for cardiovascular mortality and morbidity. Red blood cell distribution width (RDW) and neutrophil/lymphocyte ratio (NLR) can be obtained with a basic hemogram test. These parameters have been found as a predictor of mortality in the general population and in several diseases such as cardiovascular disease. Our study included 100 patients with newly diagnosed MDD and 100 healthy control patients (who had no depressive symptoms and without heart disease) admitted to our outpatient clinics. Patients with MDD were started on selective serotonin reuptake inhibitor (SSRI) treatment and followed up for 3 months. Both MDD and control patients’ laboratory tests and physical, neurological, and psychiatric examinations were performed both at diagnosis and after 3 months of treatment. In total, 100 patients with MDD were evaluated and 80 were included in our study. The control group consisted of 91 healthy individuals. The mean age was 44 ± 10.6 years for patients with MDD and 39.8 ± 11.4 years for the control group. There was no significant difference between the age for groups (P = 0.13); 55% of patients with MDD and 33% of the control group was male. NLR levels were found to be 2.55 ± 0.7 and RDW levels were found to be 14.3 ± 2.6 in patients with MDD; NLR levels were found to be 1.41 ± 0.8 and RDW levels were found to be 13.4 ± 1.8 in the control group. RDW and NLR levels were significantly higher in patients with MDD compared to the control group. The significant difference between the levels of RDW and NLR in patients with MDD and the control group was dissolved after SSRI treatment (P < 0.001). RDW [median 14.3, interquartile range (IQR) 2.8 vs. median 13.25, IQR 2.45; P < 0.001] and NLR (median 2.3, IQR 1.1 vs. median 2.0, IQR 1.15; P < 0.001) levels were significantly higher in patients with MDD compared to the control group. Our study showed that hematological inflammatory markers might be useful parameters that can be used in patients with MDD for coronary artery disease risk. Specifically, RDW and NLR seem to be more hopeful. Advanced, detailed, and larger studies are needed.