Insights into the connection between cancer and alternative splicing
Insights into the connection between cancer and alternative splicing
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DOI：
10.1016/j.tig.2007.10.001
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发表时间：
2008-01-01
影响因子：
11.4
通讯作者：
Ast, Gil
中科院分区：
文献类型：
--
作者：
Kim, Eddo;Goren, Amir;Ast, Gil
计算和实验证据已经揭示，癌细胞表达异常剪接的转录变体，表明mRNA在癌组织中比在正常组织中更频繁地选择性剪接。我们发现，癌组织表现出较低水平的选择性剪接比正常组织。此外，我们发现，在癌组织和正常组织之间的选择性剪接类型的分布不同。我们进一步显示的证据表明，在癌组织中较低水平的选择性剪接可能是剪接调节蛋白破坏的结果。
Computational and experimental evidence has revealed that cancerous cells express transcript variants that are abnormally spliced, suggesting that mRNAs are more frequently alternatively spliced in cancerous tissues than in normal ones. We show that cancerous tissues exhibit lower levels of alternative splicing than do normal tissues. Moreover, we found that the distribution of types of alternative splicing differs between cancerous and normal tissues. We further show evidence suggesting that the lower levels of alternative splicing in cancerous tissues might be a result of disruption of splicing regulatory proteins.