DNA methylation in psychosis: insights into etiology and treatment
DNA methylation in psychosis: insights into etiology and treatment
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DOI：
10.2217/epi.14.66
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发表时间：
2015-01-01
期刊：
影响因子：
3.8
通讯作者：
Singh, Shiva M.
中科院分区：
文献类型：
--
作者：
Castellani, Christina A.;Melka, Melkaye G.;Singh, Shiva M.
DNA甲基化参与精神病的证据形成了这一观点的焦点。令人感兴趣的是两组独立的实验结果，包括用抗精神病药物治疗的大鼠和精神分裂症不一致的单卵双胞胎。结果表明，抗精神病药物治疗的大鼠DNA甲基化增加，反映了药物的整体效应。这些变化中的一些也见于用抗精神病药物治疗的受影响的精神分裂症双胞胎。在不相关的实验中发现的基因和途径与神经发育和精神疾病有关。常见的原因被假设为药物使用导致的畸变。然而，这需要通过未来的研究来解决精神病中甲基化变化的起源。
Evidence for involvement of DNA methylation in psychosis forms the focus of this perspective. Of interest are results from two independent sets of experiments including rats treated with antipsychotic drugs and monozygotic twins discordant for schizophrenia. The results show that DNA methylation is increased in rats treated with antipsychotic drugs, reflecting the global effect of the drugs. Some of these changes are also seen in affected schizophrenic twins that were treated with antipsychotics. The genes and pathways identified in the unrelated experiments are relevant to neurodevelopment and psychiatric disorders. The common cause is hypothesized to be aberrations resulting from medication use. However, this needs to be established by future studies that address the origin of methylation changes in psychosis.