Association between Alanine Aminotransferase/Aspartate Aminotransferase Ratio (AST/ALT Ratio) and Coronary Artery Injury in Children with Kawasaki Disease
Association between Alanine Aminotransferase/Aspartate Aminotransferase Ratio (AST/ALT Ratio) and Coronary Artery Injury in Children with Kawasaki Disease
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DOI：
10.1155/2020/8743548
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发表时间：
2020-03-23
影响因子：
2.1
通讯作者：
Qiu, Huixian
中科院分区：
文献类型：
--
作者：
Wang, Jinxin;Li, Jiawen;Qiu, Huixian
目标。探讨川崎病（KD）患儿天冬氨酸转氨酶(AST)/丙氨酸转氨酶（ALT）比值（AST/ALT ratio， AAR）与静脉免疫球蛋白（IVIG）耐受性、冠状动脉病变（CAL）、冠状动脉动脉瘤（CAA）的关系。设计。我们回顾性研究了2678名患有KD的儿童，并将他们分为两组：低AAR组和高AAR组，AAR中位数为1.13作为分界点。比较两组在实验室数据、临床表现、冠状动脉损伤率等方面的差异。结果。在发病后2周和3-4周，低aar组的CAL发生率高于高aar组(p
Objective. To investigate the association between the aspartate aminotransferase (AST)/alanine aminotransferase (ALT) ratio (AST/ALT ratio, AAR) and intravenous immunoglobulin (IVIG) resistance, coronary artery lesions (CAL), and coronary artery aneurysms (CAA) in children with Kawasaki disease (KD). Design. We retrospectively studied 2678 children with KD and divided them into two groups: a low-AAR group and a high-AAR group with a median AAR of 1.13 as the cut-off point. The differences in laboratory data, clinical manifestations, and coronary artery damage rates were compared between the two groups. Results. The incidence of CAL was higher in the low-AAR group than in the high-AAR group at 2 and 3-4 weeks after illness onset (p