Effect of low- and high-glycemic load on circulating incretins in a randomized clinical trial.
Effect of low- and high-glycemic load on circulating incretins in a randomized clinical trial.
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一项随机临床试验中低血糖负荷和高血糖负荷对循环肠促胰岛素的影响。
DOI：
10.1016/j.metabol.2012.07.006
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发表时间：
2013
期刊：
影响因子：
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通讯作者：
Neuhouser,MarianL
中科院分区：
文献类型：
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作者：
Runchey,ShaunaS;Valsta,LiisaM;Schwarz,Yvonne;Wang,Chiachi;Song,Xiaoling;Lampe,JohannaW;Neuhouser,MarianL
低血糖负荷饮食降低餐后血糖和胰岛素反应;然而，血糖负荷对循环肠促胰岛素浓度的影响尚不清楚。我们旨在评估饮食血糖负荷对空腹和餐后血糖、胰岛素和肠促胰岛素（即，葡萄糖依赖性促胰岛素多肽（GIP）和胰高血糖素样肽-1（GLP-1））浓度，并检查肥胖对效果的影响。材料和方法我们进行了一项单中心、随机对照交叉喂养试验，其中一部分参与者进行了餐后测试。参与者是从当地的西雅图地区招募的。我们招募了89名超重肥胖（BMI 28.0-39.9kg/m2）和瘦（BMI 18.5-25.0kg/m2）的健康成年人。参与者以随机顺序食用了两种28天的、维持体重的高血糖负荷和低血糖负荷控制饮食。主要结果测量是餐后循环葡萄糖、胰岛素、GIP和GLP-1浓度，在测试早餐后。在完成两种饮食干预的80名参与者中，16名进行了肠促胰岛素测试，并组成了分析组。在每28天的高和低血糖负荷饮食后，胰岛素、葡萄糖、GIP和GLP-1的平均空腹浓度没有显著差异。餐后葡萄糖、胰岛素和GIP的平均综合浓度较高，（1504±476mg/dL/min，p<0.01; 2012±644μU/mL/min，p<0.01和15517± 4062 pg/mL/min，p<0.01）和GLP-1较低（−81.6±38.5 pmol/L/min，p<0.03），与低血糖负荷早餐相比。体脂并没有显着修改血糖负荷对代谢outcomes.CONCLUSIONSHIGH-glycemic负荷饮食在体重维持健康的个体导致较高的餐后GIP和较低的餐后GLP-1浓度的影响。未来的研究评估膳食血糖负荷调控肠促胰岛素的影响将有助于建立糖尿病营养指南。
OBJECTIVELow-glycemic load diets lower post-prandial glucose and insulin responses; however, the effect of glycemic load on circulating incretin concentrations is unclear. We aimed to assess effects of dietary glycemic load on fasting and post-prandial glucose, insulin and incretin (i.e., glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1)) concentrations and to examine for effect modification by adiposity.MATERIALS AND METHODSWe conducted a single-center, randomized controlled crossover feeding trial in which a subset of participants had post-prandial testing. Participants were recruited from the local Seattle area. We enrolled 89 overweight–obese (BMI 28.0–39.9kg/m2) and lean (BMI 18.5–25.0kg/m2) healthy adults. Participants consumed two 28-day, weight-maintaining high- and low-glycemic load controlled diets in random order. Primary outcome measures were post-prandial circulating concentrations of glucose, insulin, GIP and GLP-1, following a test breakfast.RESULTSOf the 80 participants completing both diet interventions, 16 had incretin testing and comprise the group for analyses. Following each 28-day high- and low-glycemic load diet, mean fasting concentrations of insulin, glucose, GIP and GLP-1 were not significantly different. Mean integrated post-prandial concentrations of glucose, insulin and GIP were higher (1504±476mg/dL/min, p<0.01; 2012±644μU/mL/min, p<0.01 and 15517±4062pg/mL/min, p<0.01, respectively) and GLP-1 was lower (−81.6±38.5 pmol/L/min, p<0.03) following the high-glycemic load breakfast as compared to the low-glycemic load breakfast. Body fat did not significantly modify the effect of glycemic load on metabolic outcomes.CONCLUSIONSHigh-glycemic load diets in weight-maintained healthy individuals lead to higher post-prandial GIP and lower post-prandial GLP-1 concentrations. Future studies evaluating dietary glycemic load manipulation of incretin effects would be helpful for establishing diabetes nutrition guidelines.