Hydrophilic interpenetrating polymer networks of poly(dimethyl siloxane) (PDMS) as biomaterial for cochlear implants
Hydrophilic interpenetrating polymer networks of poly(dimethyl siloxane) (PDMS) as biomaterial for cochlear implants
复制标题
DOI：
10.1163/156856206775997287
复制
发表时间：
2006-01-01
影响因子：
3.6
通讯作者：
Simjoo, M
中科院分区：
文献类型：
--
作者：
Abbasi, F;Mirzadeh, H;Simjoo, M
对聚二甲基硅氧烷（PDMS）进行本体改性，研制出一种能紧贴鼓阶内壁的新型耳蜗内电极。采用结构化方法改变PDMS本体和表面的亲水性，制备了互穿聚合物网络（IPNs）。合成了一系列基于聚二甲基硅氧烷（PDMS）和聚丙烯酸（PAAc）的互穿聚合物网络（IPNs），并通过衰减全反射傅里叶变换红外光谱（ATFT）、水接触失重法、动态力学热分析（DSC）和剥离强度测试等手段对IPNs进行了表征。在ST的透明模型内评估实际尺寸的制造电极的性能，该透明模型填充有盐水。研究了L929成纤维细胞在材料上的细胞行为。
Poly(dimethyl siloxane) (PDMS) was bulk-modified to develop a new intra-cochlear electrode that can closely hug the inner wall of scala tympani (ST). The hydrophilicity of bulk and surface of PDMS was changed using a structural method for preparation of interpenetrating polymer networks (IPNs). A series of IPNs, based on PDMS and poly(acrylic acid) (PAAc), was synthesized and characterized by means of attenuated total reflectance Fourier transform infrared spectroscopy, water contact-an,de measurement, dynamic mechanical thermal analysis and peel strength tests. The performances of actual-sized fabricated electrodes were assessed inside a transparent model of ST, which was filled with saline. The cell behavior of L929 fibroblasts on materials was studied in vitro.