Simultaneous detection and quantitation of highly water-soluble herbicides in serum using ion-pair liquid chromatography-tandem mass spectrometry
Simultaneous detection and quantitation of highly water-soluble herbicides in serum using ion-pair liquid chromatography-tandem mass spectrometry
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DOI：
10.1016/j.jchromb.2008.10.042
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发表时间：
2008-12-15
影响因子：
3
通讯作者：
Lee, Ching-Kuo
中科院分区：
文献类型：
--
作者：
Wang, Kuang-Chuan;Chen, Shih-Ming;Lee, Ching-Kuo
我们报告的同时筛选高极性，水溶性，挥发性较低的除草剂，包括草甘膦，草铵膦，百草枯，敌草快，在血清中使用液相色谱-质谱。使用Strata-XC柱通过固相萃取分离除草剂。选择七氟丁酸溶液作为离子对液相色谱的移动的相。使用质谱法进行分析，并针对所有分析物的正模式操作进行优化。对血清样本进行筛选，以确定是否存在以下浓度的除草剂：草甘膦为5 ng/mL，草铵膦为2 ng/mL，敌草快为1 ng/mL，百草枯为5 ng/mL。这是第一个同时检测这些化合物的报告。(C)2008 Elsevier B. V.保留所有权利。
We report the simultaneous screening of highly polar, water-soluble, and less-volatile herbicides, including glyphosate, glufosinate, paraquat, and diquat, in serum using liquid chromatography-mass spectrometry. The herbicides were separated by solid-phase extraction using a Strata-XC cartridge. A heptafluorobutyric acid solution was chosen as the mobile phase for ion-pair liquid chromatography. Mass spectrometry was used for analysis and was optimized for operation in the positive mode for all analytes. The serum specimens were screened for the presence of the herbicides at the following concentrations: 5 ng/mL for glyphosate, 2 ng/mL for glufosinate, 1 ng/mL for diquat, and 5 ng/mL for paraquat. This is the first report on the simultaneous detection of these compounds. (C) 2008 Elsevier B.V. All rights reserved.