Generative design approach to combine architected Voronoi foams with porous collagen scaffolds to create a tunable composite biomaterial.
Generative design approach to combine architected Voronoi foams with porous collagen scaffolds to create a tunable composite biomaterial.
复制标题
DOI：
10.1016/j.actbio.2023.10.005
复制
发表时间：
2023-10
影响因子：
9.7
通讯作者：
Marley J. Dewey;R. S. H. Chang;Andrey V. Nosatov;Katherine Janssen;S. Crotts;S. J. Hollister;B. Harley
中科院分区：
文献类型：
--
作者：
Marley J. Dewey;R. S. H. Chang;Andrey V. Nosatov;Katherine Janssen;S. Crotts;S. J. Hollister;B. Harley
用于肌肉骨骼缺损的再生生物材料必须解决多尺度力学挑战。修复颅颌面骨缺损，这往往是大的和不规则的形状，需要植入物和缺损边缘之间的紧密适形接触，以帮助愈合。虽然矿化胶原支架可以促进间充质干细胞体外成骨分化和体内成骨，但其机械性能不足以用于手术平移。我们报告了一种生成设计方法，通过将宏观尺度的聚合物Voronoi网嵌入矿化胶原支架中来创建支架-网复合材料。结构化泡沫增强复合材料的力学性能由严格的预测模量方程定义。我们发现双相复合材料在加载过程中局部应变。此外，平面和3D网状支架复合材料可以快速成形以帮助适形拟合。Voronoi基复合材料克服了传统的孔隙率力学关系的限制，同时使再生植入物的快速成型，以适应复杂的缺陷独特的个别patients.Statement的SignificanceBiomaterial战略（颅颌面）骨再生往往受到限制的大小和复杂的几何形状的缺陷。Voronoi结构是具有可调机械性能的开孔泡沫，其主要用于计算。我们描述了生成设计策略，通过3D打印创建Voronoi泡沫，然后将它们嵌入成骨矿化胶原支架中，形成多尺度复合生物材料。Voronoi结构具有可预测和可定制的模量，允许染色定位到复合材料的限定区域，并允许适形拟合以影响边缘，从而帮助手术实用性并改善宿主-生物材料相互作用。基于Voronoi泡沫的多尺度复合材料代表了一种适应性强的设计方法，以应对大规模骨修复的重大挑战。
Regenerative biomaterials for musculoskeletal defects must address multi-scale mechanical challenges. Repairing craniomaxillofacial bone defects, which are often large and irregularly shaped, requires close conformal contact between implant and defect margins to aid healing. While mineralized collagen scaffolds can promote mesenchymal stem cell osteogenic differentiationin vitroand bone formationin vivo,their mechanical performance is insufficient for surgical translation. We report a generative design approach to create scaffold-mesh composites by embedding a macro-scale polymeric Voronoi mesh into the mineralized collagen scaffold. The mechanics of architected foam reinforced composites are defined by a rigorous predictive moduli equation. We show biphasic composites localize strain during loading. Further, planar and 3D mesh-scaffold composites can be rapidly shaped to aid conformal fitting. Voronoi-based composites overcome traditional porosity-mechanics relationship limits while enabling rapid shaping of regenerative implants to conformally fit complex defects unique for individual patients.Statement of SignificanceBiomaterial strategies for (craniomaxillofacial) bone regeneration are often limited by the size and complex geometry of the defects. Voronoi structures are open-cell foams with tunable mechanical properties which have primarily been used computationally. We describe generative design strategies to create Voronoi foams via 3D-printing then embed them into an osteogenic mineralized collagen scaffold to form a multi-scale composite biomaterial. Voronoi structures have predictable and tailorable moduli, permit stain localization to defined regions of the composite, and permit conformal fitting to effect margins to aid surgical practicality and improve host-biomaterial interactions. Multi-scale composites based on Voronoi foams represent an adaptable design approach to address significant challenges to large-scale bone repair.