Single event molecular signalling for estimation and control
Single event molecular signalling for estimation and control
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用于估计和控制的单事件分子信号传导
DOI：
10.23919/ecc.2013.6669774
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发表时间：
2013
期刊：
影响因子：
--
通讯作者：
G. Vinnicombe
中科院分区：
文献类型：
--
作者：
K. Parag;G. Vinnicombe
细胞生物学的特征在于低分子数量和耦合的随机化学反应，其中固有噪声渗透并主导分子之间的相互作用。最近的工作[9]表明，在这样的环境中，控制和估计分子种群的准确性存在严格的限制。这些限制是基于目标分子的连续扩散近似（尽管系统的其余部分是非线性和离散的）。[9]的主要结果假设信号种类的出生率线性依赖于靶分子群体大小。在本文中，我们调查的情况下，当整个系统保持离散，任意的非线性耦合之间的目标分子和下游信号分子允许。在这种情况下，通过仅依赖于控制和信号传导反应的事件触发性质，可以定义在某些参数方案中实现改进的性能的非线性反应速率调节方案。这些方案似乎不具有生物学相关性，这就提出了一个问题，即什么是获得具有生物学意义结果的适当假设。
Cell biology is characterised by low molecule numbers and coupled stochastic chemical reactions with intrinsic noise permeating and dominating the interactions between molecules. Recent work [9] has shown that in such environments there are hard limits on the accuracy with which molecular populations can be controlled and estimated. These limits are predicated on a continuous diffusion approximation of the target molecule (although the remainder of the system is non-linear and discrete). The principal result of [9] assumes that the birth rate of the signalling species is linearly dependent on the target molecule population size. In this paper, we investigate the situation when the entire system is kept discrete, and arbitrary non-linear coupling is allowed between the target molecule and downstream signalling molecules. In this case it is possible, by relying solely on the event triggered nature of control and signalling reactions, to define non-linear reaction rate modulation schemes that achieve improved performance in certain parameter regimes. These schemes would not appear to be biologically relevant, raising the question of what are an appropriate set of assumptions for obtaining biologically meaningful results.