Lopinavir-ritonavir: Effects on endothelial cell function in healthy subjects
Lopinavir-ritonavir: Effects on endothelial cell function in healthy subjects
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DOI：
10.1086/503807
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发表时间：
2006-06-01
影响因子：
6.4
通讯作者：
Gladwin, MT
中科院分区：
文献类型：
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作者：
Grubb, JR;Dejam, A;Gladwin, MT
为了区分抗逆转录病毒药物对内皮细胞的影响及其对免疫功能、病毒载量和血脂异常的继发性影响，对6例非人类免疫缺陷病毒感染者给予洛比那韦-利托那韦治疗1个月，并在前臂血流量的基础上测定治疗对内皮细胞功能的影响。令人惊讶的是，在应用洛比那韦-利托那韦后，血管内皮依赖性扩张剂乙酰胆碱的绝对前臂血流反应显著增加(P=0.03)，而在NG-单甲基-L-精氨酸特异性抑制NO合成酶的过程中，前臂血流量下降的程度更大。因此，在这一小群受试者中，洛匹那韦-利托那韦的短期治疗似乎并不直接促进内皮细胞功能障碍。
To differentiate between the effects that antiretroviral drugs have on the endothelium and the secondary effects that they have on immune function, viral load, and dyslipidemia, 6 non - human immunodeficiency virus - infected human subjects were treated with lopinavir-ritonavir for 1 month and, on the basis of forearm blood flow, the treatment's effects on endothelial cell function were measured. Surprisingly, after exposure to lopinavir-ritonavir, absolute forearm blood-flow responses to the endothelium-dependent vasodilator, acetylcholine, increased significantly (P = .03), and forearm blood flow decreased to a greater extent during specific inhibition of NO synthase by NG-monomethyl-L-arginine. Thus, in this small cohort of subjects, short-term treatment with lopinavir-ritonavir does not appear to directly promote endothelial cell dysfunction.