Myocardial and coronary vascular effects of salbutamol.
Myocardial and coronary vascular effects of salbutamol.
复制标题
沙丁胺醇对心肌和冠状血管的影响。
作者：
G. Ross
麻醉开胸犬冠状动脉内注射异丙肾上腺素和沙丁胺醇可增加冠状动脉流量和心肌力。异丙肾上腺素作为冠状血管扩张剂的效力是沙丁胺醇的3至8倍，作为正性肌力药的效力约为沙丁胺醇的80倍。这些观察结果表明，冠状动脉β肾上腺素受体类似于其他血管平滑肌，而不是心肌。
Intracoronary administration of isoprenaline and salbutamol to anaesthetized, open-chest dogs increased coronary flow and myocardial force. Isoprenaline was 3 to 8 times more potent than salbutamol as a coronary vasodilator and approximately 80 times more potent as an inotropic agent. These observations suggest that the coronary beta adrenotropic receptors resemble those of other vascular smooth muscle rather than those of cardiac muscle.