Design and concise synthesis of a novel type of green fluorescent protein chromophore analogue.
Design and concise synthesis of a novel type of green fluorescent protein chromophore analogue.
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DOI：
10.1021/ol301901e
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发表时间：
2012-08
期刊：
影响因子：
5.2
通讯作者：
M. Ikejiri;Moe Tsuchino;Yoshiko Chihara;Takao Yamaguchi;T. Imanishi;S. Obika;K. Miyashita
中科院分区：
文献类型：
--
作者：
M. Ikejiri;Moe Tsuchino;Yoshiko Chihara;Takao Yamaguchi;T. Imanishi;S. Obika;K. Miyashita
A small molecular model compound for the green fluorescent protein chromophore was readily synthesized by a novel condensation reaction of (thio)imidate with imino-ester via an aziridine intermediate. This compound showed fluorescence in the solid and frozen solution states but not in the solution state. Its fluorescent property was successfully applied in the detection of dsDNA.
