THE EFFECT OF AN ACUTE NICOTINE INFUSION ON THE LOCAL CEREBRAL GLUCOSE-UTILIZATION OF THE AWAKE RAT
THE EFFECT OF AN ACUTE NICOTINE INFUSION ON THE LOCAL CEREBRAL GLUCOSE-UTILIZATION OF THE AWAKE RAT
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DOI：
10.1016/0006-8993(87)90622-6
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发表时间：
1987-01-06
期刊：
影响因子：
2.9
通讯作者：
KUSCHINSKY, W
中科院分区：
文献类型：
--
作者：
GRUNWALD, F;SCHROCK, H;KUSCHINSKY, W
用Sokoloff等人描述的定量放射自显影2-脱氧-d-[1-14C]葡萄糖方法，研究了急性输注尼古丁对大鼠中枢神经系统局部脑葡萄糖利用(LCGU)的影响。尼古丁按0.5g/kg/m in和5μg/kg/m in 3个剂量给药。由此产生的尼古丁血浆浓度为10/39/114 ng/ml血浆。在实验过程中，血压、心率、体温、红细胞压积、酸碱状态和血糖浓度均无或略有变化。尼古丁对黑质(致密部)、上丘(浅灰层)、脚间核和扣带皮质(P<；0.05)、外侧膝状体、视交叉、丘脑前腹侧核、前内侧核和乳头体(P<；0.05)的LCGU均有剂量依赖性增加作用。对于大多数LCGU增加的结构，其他组报告了尼古丁的高区域受体结合(乳头体和视交叉除外)。结论：尼古丁对局部脑区的功能活动有明显影响。
The effect of acute infusion of nicotine on local cerebral glucose utilization (LCGU) was studied in discrete regions of the central nervous system of the rat by means of the quantitative autoradiographic 2-deoxy-d-[1-14C]glucose method described by Sokoloff et al.26. Nicotine was administered in 3 dosages: 0.5 μg/kg/min and 5 μg/kg/min. The resulting plasma concentrations of nicotine were 10/39/114 ng/ml plasma. During the experiment, blood pressure, heart rate, body temperature, hematocrit, acid-base status and plasma glucose concentration showed no — or minor — changes. Nicotine significantly increased LCGU in a dose-dependent manner in the following 9 of 45 examined structures: substantia nigra (compact part), superior colliculus (superficial grey layer), interpeduncular nucleus and cingulate cortex (P< 0.05); lateral geniculate body, optic chiasm, anteroventral and anteromedial nucleus of thalamus and mamillary body (P< 0.05). For most of these structures with increased LCGU, other groups have reported a high regional receptor binding of nicotine (exception: mamillary body and optic chiasm). It is concluded that nicotine has distinct effects on the functional activity of localized brain areas.