Maternal perchlorate exposure in pregnancy and altered birth outcomes.
Maternal perchlorate exposure in pregnancy and altered birth outcomes.
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母亲在怀孕期间接触高氯酸盐并改变出生结果。
DOI：
10.1016/j.envres.2017.05.030
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发表时间：
2017
影响因子：
8.3
通讯作者：
Steinmaus,Craig
中科院分区：
文献类型：
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作者：
Rubin,Rainbow;Pearl,Michelle;Kharrazi,Martin;Blount,BenjaminC;Miller,MarkD;Pearce,ElizabethN;Valentin-Blasini,Liza;DeLorenze,Gerald;Liaw,Jane;Hoofnagle,AndrewN;Steinmaus,Craig
背景高药物剂量的高氯酸盐被认为会减少甲状腺激素的产生，而甲状腺激素是胎儿发育的关键因素。在一大群独特暴露的孕妇队列中，我们最近确定了环境中高氯酸盐暴露与怀孕期间母亲甲状腺激素下降之间的关联。方法收集2000-2003年圣地亚哥县1957对母婴尿液中的高氯酸盐、血清甲状腺激素浓度、出生体重、胎龄、尿中硝酸盐、硫氰酸盐和碘。高氯酸盐暴露与出生结局之间的关系通过线性和Logistic回归分析来检验，调整了母亲的年龄、体重、种族/民族和其他因素。然而，在仅限于男婴的分析中，母亲的高氯酸盐浓度与出生体重的增加有关(β=143.1 gm，p=0.01)，特别是在早产儿中(β=829.1 g，p<；0.001)。高氯酸盐与男性早产≥2 5 0 0 g相关(优势比=3.0 3，95%可信区间=1.0 9~8.4 0，p趋势=0.0 3)。在女性中没有发现类似的关联。结论这是第一项确定高氯酸盐与出生体重增加之间的关联的研究。需要进一步的研究来探索我们发现的与婴儿性别、早产和其他因素有关的差异。鉴于高氯酸盐的接触无处不在，而且出生结局改变后可能会产生长期影响，未来对高氯酸盐的研究可能具有广泛的公共卫生重要性。
BackgroundAt high medicinal doses perchlorate is known to decrease the production of thyroid hormone, a critical factor for fetal development. In a large and uniquely exposed cohort of pregnant women, we recently identified associations between environmental perchlorate exposures and decreased maternal thyroid hormone during pregnancy. Here, we investigate whether perchlorate might be associated with birthweight or preterm birth in the offspring of these women.MethodsMaternal urinary perchlorate, serum thyroid hormone concentrations, birthweight, gestational age, and urinary nitrate, thiocyanate, and iodide were collected in 1957 mother-infant pairs from San Diego County during 2000–2003, a period when the county's water supply was contaminated with perchlorate. Associations between perchlorate exposure and birth outcomes were examined using linear and logistic regression analyses adjusted for maternal age, weight, race/ethnicity, and other factors.ResultsPerchlorate was not associated with birth outcomes in the overall population. However, in analyses confined to male infants, log10maternal perchlorate concentrations were associated with increasing birthweight (β=143.1 gm, p=0.01), especially among preterm births (β=829.1 g, p<0.001). Perchlorate was associated with male preterm births ≥2500 g (odds ratio=3.03, 95% confidence interval=1.09–8.40, p-trend=0.03). Similar associations were not seen in females.ConclusionsThis is the first study to identify associations between perchlorate and increasing birthweight. Further research is needed to explore the differences we identified related to infant sex, preterm birth, and other factors. Given that perchlorate exposure is ubiquitous, and that long-term impacts can follow altered birth outcomes, future research on perchlorate could have widespread public health importance.