HBXIP: a potential prognosis biomarker of colorectal cancer which promotes invasion and migration via epithelial-mesenchymal transition
HBXIP: a potential prognosis biomarker of colorectal cancer which promotes invasion and migration via epithelial-mesenchymal transition
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HBXIP：结直肠癌的潜在预后生物标志物，通过上皮间质转化促进侵袭和迁移
DOI：
10.1016/j.lfs.2020.117354
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发表时间：
2020-03-15
期刊：
影响因子：
6.1
通讯作者：
Liu, Shuangping
中科院分区：
文献类型：
--
作者：
Wang, Xuanyu;Feng, Qi;Liu, Shuangping
B型肝炎病毒X相互作用蛋白（HBXIP）在多种肿瘤中高度表达，但其表达与结直肠癌（CRC）的临床意义及分子机制的关系尚不清楚。我们选取了186例大肠癌组织，采用免疫组化方法分析HBXIP的表达与大肠癌临床病理特征的关系。进行迁移和侵袭实验以检查HBXIP对CRC细胞转移的影响。此外，我们还通过蛋白质印迹法探讨了HBXIP调节CRC细胞转移的可能分子机制。我们的数据表明HBXIP在CRC组织中过表达。HBXIP高表达与结直肠癌患者的转移和较短的生存时间相关，并作为预后不良的独立因素。此外，HBXIP通过增强上皮-间质转化（EMT）过程促进CRC转移。我们的研究结果提供了第一个证据，HBXIP诱导EMT促进转移，并预测CRC的不良预后。因此，HBXIP可能成为CRC治疗的新靶点。
Hepatitis B X-interacting protein (HBXIP) is highly expressed in many cancers, but the correlation between the expression of HBXIP and the clinical significance and underlying molecular mechanisms in colorectal cancer (CRC) is still unclear. We selected 186 specimens from CRC patients for analyzing the relationship between the expression of HBXIP and the clinical-pathological features by immunohistochemistry. Migration and invasion experiments were performed to examine the effect of HBXIP on CRC cell metastasis. Besides, we also explored the possible molecular mechanism of HBXIP regulation of CRC cell metastasis by Western blot. Our data indicated that the HBXIP was overexpressed in CRC tissues. High HBXIP expression was correlated with metastasis and shorter survival times in patients with CRC and served as an independent factor for poor prognosis. Moreover, HBXIP promotes CRC metastasis by enhancing the epithelial-mesenchymal transition (EMT) process. Our findings provide the first evidence that HBXIP induces EMT to promote metastasis and predicts the poor prognosis of CRC. Therefore, HBXIP may become a new target for CRC treatment.