Neurochemical sex differences in adult ADHD patients: an MRS study.
Neurochemical sex differences in adult ADHD patients: an MRS study.
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DOI：
10.1186/s13293-019-0264-4
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发表时间：
2019-10-29
影响因子：
7.9
通讯作者：
Perlov, Evgeniy
中科院分区：
文献类型：
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作者：
Endres, Dominique;Tebartz van Elst, Ludger;Perlov, Evgeniy
目的：注意缺陷多动障碍（ADHD）是一种常见的神经发育障碍。相关的性别差异在生殖医学进行了讨论。本研究比较了年龄和智商匹配的成年男性（mADHD）和女性（fADHD）ADHD patients.METHODS：我们研究了48（ACC）和42（小脑）男性/女性对成人ADHD患者的前扣带皮层（ACC）和左小脑半球的神经代谢。采用单体素磁共振波谱（MRS）研究肌酸（Cre）、总胆碱（t-Cho）、谷氨酸+谷氨酰胺（Glx）、N-乙酰天冬氨酸和肌醇。使用稳健线性回归比较mADHD和fADHD组。显着性水平进行了校正的多个测试使用Benjamini-Hochberg approach.RESULTS：对于ACC，Cre（p=0.008）和t-Cho（p=0.004）的信号显示出显着的影响，年龄的协变量以及性别和年龄的相互作用（Cre：p=0.033; t-Cho：p=0.040）。对于Glx信号，还可以观察到性别和年龄的相互作用（p=0.033）。对于小脑神经代谢产物，t-Cho（p=0.049）和Glx（p=0.049）的信号表现出显着的影响因素sex.CONCLUSION：这是迄今为止最大的研究，以分析成人ADHD患者脑神经化学的性别差异。ACC中不同的年龄依赖性t-Cho信号可能与mADHD的延迟髓鞘化有关。进一步的MRS研究在成人多动症，占可能的性别影响，是必要的，以验证目前的研究结果。
OBJECTIVE: Attention-deficit/hyperactivity disorder (ADHD) is a common neurodevelopmental disorder. Relevant sex differences in symptomatology are discussed. This study compared brain neurometabolism in the anterior cingulate cortex (ACC) and left cerebellar hemisphere in age- and IQ-matched adult male (mADHD) and female (fADHD) ADHD patients.METHODS: We studied 48 (ACC) and 42 (cerebellum) male/female pairs of stimulant-free patients with adult ADHD. Single voxel magnetic resonance spectroscopy (MRS) was used to investigate creatine (Cre), total choline (t-Cho), glutamate+glutamine (Glx), N-acetylaspartate, and myo-inositol. The mADHD and fADHD groups were compared using robust linear regression. The level of significance was corrected for multiple tests using the Benjamini-Hochberg approach.RESULTS: For the ACC, the signals of Cre (p=0.008) and t-Cho (p=0.004) showed significant effects of the agecovariate as well as an interaction of sex and age (Cre: p=0.033; t-Cho: p=0.040). For the Glx signal, an interaction of sex and age could also be observed (p=0.033). For cerebellar neurometabolites, the signals of t-Cho (p=0.049) and Glx (p=0.049) showed significant effects of the factor sex.CONCLUSION: This is the largest study yet to analyze sex differences in brain neurochemistry in adult patients with ADHD. Different age-dependent t-Cho signals in the ACC might be associated with delayed myelinization in mADHD. Further MRS studies in adult ADHD, accounting for possible sex effects, are warranted to validate the present findings.