ETHANOL OXIDATION BY RAT-BRAIN INVIVO
ETHANOL OXIDATION BY RAT-BRAIN INVIVO
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DOI：
10.1111/j.1530-0277.1980.tb04833.x
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发表时间：
1980-01-01
影响因子：
3.2
通讯作者：
HEIKKILA, R
中科院分区：
文献类型：
--
作者：
COHEN, G;SINET, PM;HEIKKILA, R
大脑能代谢乙醇吗？我们提供的数据表明，脑过氧化氢酶与内源性h2o2一起将在体内氧化乙醇。该方法基于体内3 -氨基- 1,2.4 -三唑对H2O2依赖性脑过氧化氢酶的抑制作用以及乙醇的预防作用。氨基三唑对过氧化氢酶的不可逆抑制作用是通过（过氧化氢酶- H2O2）化合物I与氨基三唑的反应进行的。被化合物i氧化的化合物可以防止抑制作用。乙醇就是这样一种化合物。预先给药乙醇可以防止体内脑过氧化氢酶的抑制，这是乙醇在大鼠脑中氧化为乙醛的间接证据。组织中过氧化氢酶的含量代表了脑实质中的过氧化氢酶，红细胞和毛细血管已被排除在外。乙醇没有改变脑内氨三唑的水平。这些结果首次证明了乙醇在活体大脑中的氧化作用。
Can brain metabolize ethanol? We present data demonstrating that brain catalase in conjunction with endogenous H2O2will oxidize ethanol in vivo. The method is based on an H2O2‐dependent inhibition of brain catalase in vivo by 3‐amino‐1,2.4‐triazole and its prevention by ethanol. The irreversible inhibition of catalase by aminotriazole is known to proceed via the reaction of (catalase‐H2O2) compound I with aminotriazole. Inhibition can be prevented by compounds that are oxidized by compound I. Ethanol is one such compound. Prevention of the inhibition of brain catalase in vivo by prior administration of ethanol constitutes indirect evidence for the oxidation of ethanol to acetalde‐hyde in rat brain. The catalase content of the tissues represented catalase in the brain parenchyma, from which erythrocytes and capillaries had been excluded. Ethanol did not alter the levels of aminotriazole in brain. These results constitute the first demonstration of ethanol oxidation by living brain.