SYMPATHETIC SKIN-RESPONSE ABNORMALITIES IN AMYOTROPHIC-LATERAL-SCLEROSIS
SYMPATHETIC SKIN-RESPONSE ABNORMALITIES IN AMYOTROPHIC-LATERAL-SCLEROSIS
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DOI：
10.1002/mus.880160907
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发表时间：
1993-09-01
期刊：
影响因子：
3.4
通讯作者：
JERUSALEM, F
中科院分区：
文献类型：
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作者：
DETTMERS, C;FATEPOUR, D;JERUSALEM, F
对25例肌萎缩侧索硬化（ALS）患者进行交感神经皮肤反应（SSR）检查，以评估自主神经系统受累情况。22例年龄匹配的正常人和6例肌营养不良症患者作为对照。所有正常志愿者和所有肌营养不良症患者的SSR均完好无损。ALS患者的SSR潜伏期较正常人延长（2.29 ± 0.28 vs 2.13 ± 0.16 s，P < 0.05）。10例ALS患者（40%）的一侧或双侧下肢SSR缺失。在没有自主神经功能衰竭临床表现的ALS患者中，SSR的缺失或异常潜伏期提示除了运动系统之外，还涉及自主神经系统。(C)John Wiley & Sons，Inc.
The sympathetic skin response (SSR) was evaluated in 25 patients with amyotrophic lateral sclerosis (ALS) to assess for involvement of the autonomic nervous system. Twenty-two age-matched normals and 6 patients with muscular dystrophy served as controls. The SSR was intact in all normal volunteers and all patients with muscular dystrophy. The mean SSR latency in the ALS patients was prolonged compared to that of normals (2.29 +/- 0.28 versus 2.13 +/- 0.16 s, P < 0.05). The SSR was absent in one or both legs of 10 ALS patients (40%). Absence or abnormal latency of SSR in patients with ALS without clinical findings of autonomic failure suggests involvement of the autonomic nervous s stem in addition to the motor s tem. (C) 1993 John Wiley & Sons, Inc.