Cumulative incidence of pandemic influenza A (H1N1) 2009 by a community-based serological cohort study in Selenghe Province, Mongolia
Cumulative incidence of pandemic influenza A (H1N1) 2009 by a community-based serological cohort study in Selenghe Province, Mongolia
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DOI：
10.1111/j.1750-2659.2012.00334.x
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发表时间：
2012-11-01
影响因子：
4.4
通讯作者：
Nymadawa, Pagbajabyn
中科院分区：
文献类型：
--
作者：
Burmaa, Alexanderyn;Tsatsral, Sosorbaramyn;Nymadawa, Pagbajabyn
背景2009年10月至12月，蒙古发生了2009年甲型H1N1流感大流行的大规模社区暴发。通过检测在蒙古色伦河省第一波大流行前后收集的配对血清，在一般人群中进行了血清学研究。目的了解色棱河省不同年龄段人群甲型H1N1流感累计发病情况，为制定有效的预防措施提供依据。使用血凝素抑制（HI）和微量中和（MN）试验测定A/加州/07/2009 pdm的抗体滴度。结果HI、MN、HI和MN联合检测的累计感染率分别为28.8%（76/264）、35.2%（93/264）和25.0%（66/264）。各年龄组的累积感染率各不相同，24岁和59岁儿童的累积感染率较高。估计整个人群的总累积感染率为23.0%（4946/21 460），HI，30.2%（6473/21 460）由MN，18.8%结论色棱河省甲型H1N1流感病毒感染率约占全省总人口的1/4。2009年病毒在第一波大流行期间。
Background Large community outbreaks of pandemic A (H1N1) 2009 occurred between October and December 2009 in Mongolia. A serological study was conducted among the general population by testing paired sera collected before and after the first wave of pandemic in Selenghe province, Mongolia. None of the study participants had been vaccinated for pandemic A (H1N1) 2009 before the second samples were collected.Objective The objective of this study was to estimate cumulative incidence of pandemic A (H1N1) 2009 in different age-groups of Selenghe province residents.Methods After informed consent was obtained from apparently healthy volunteers, the paired sera and background information were collected. Antibody titers were measured using hemagglutinin inhibition (HI) and microneutralization (MN) assays for A/California/07/2009pdm. A fourfold rise in antibody titers was regarded as the evidence of infection.Results The overall cumulative incidences in the study group for all ages were 28.8% (76/264) by HI, 35.2% (93/264) by MN, and 25.0% (66/264) by both HI and MN. Cumulative incidences of infection varied among age-groups, with children aged 24 and 59 years having high cumulative incidence of infection. Overall cumulative incidences of infection in the whole population were estimated to be 23.0% (4946/21 460) by HI, 30.2% (6473/21 460) by MN, and 18.8% (4036/21 460) by both HI and MN.Conclusions This study indicates that about one-fourth of the total population in Selenghe province was infected with pandemic A (H1N1) 2009 virus during the first wave of the pandemic.