Mortality and cancer incidence in a nickel cohort
Mortality and cancer incidence in a nickel cohort
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DOI：
10.1093/occmed/kqp197
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发表时间：
2010-05-01
影响因子：
5.1
通讯作者：
Semenciw, R.
中科院分区：
文献类型：
--
作者：
Lightfoot, N.;Berriault, C.;Semenciw, R.
目的研究加拿大安大略省萨德伯里一家主要镍和铜生产商的一组男性镍工人的癌症发病率和死亡率。方法从1964年1月到2001年12月，将名义名册和工作经历信息与安大略省的健康数据联系起来，并对安大略省人口的死亡率和癌症发病率进行比较。结果死亡1984例（19%），癌变1127例（11%）（n = 10 253）。事故、中毒和暴力导致的死亡率显著上升；首次受雇未满15年的人员中可能与工作有关的事故[标准化死亡率(SMR) = 133, 95% CI: 111-158；SMR = 241, 95% CI分别为159-351]，而对于那些自第一次雇佣bb0 = 15年的事故（SMR = 123, 95% CI: 104-144）。在6个月至14年工作经验的人群中，事故、中毒和暴力发生率显著升高，在15-29年工作经验的人群中，肺癌发病率和死亡率显著升高（SMR = 128, 95% CI: 107-153）。在20世纪40年代和60年代受雇的人中，肺癌发病率显著上升。结论随首次入职时间的增加、早期入职时间的增加以及入职时间的延长，队列工人和井下工人的肺癌死亡率和发病率均有显著升高。由于职业病因无法确定，需要进一步的病因学研究。
Aims To examine cancer incidence and mortality, concurrently, for a cohort of male nickel workers at a major nickel and copper producer in Sudbury, Ontario, Canada.Methods From January 1964 to December 2001, nominal roll and work history information were linked to Ontario health data and mortality and cancer incidence were compared to the Ontario population.Results There were 1984 (19%) deaths and 1127 (11%) incident cancers (n = 10 253). Significant elevations in mortality were observed for accidents, poisoning and violence; for possibly job-related accidents among those with < 15 years since first hire [standardized mortality ratio (SMR) = 133, 95% CI: 111-158; SMR = 241, 95% CI: 159-351, respectively] and for accidents in those with >= 15 years since first hire (SMR = 123, 95% CI: 104-144). Significant elevations were also observed for accidents, poisoning and violence for those with 6 months to 14 years work experience and for lung cancer incidence and mortality for those with 15-29 years work experience (SMR = 128, 95% CI: 107-153). Incident lung cancers were significantly elevated for those hired in the 1940s and 1960s.Conclusions Significant lung cancer mortality and incidence elevations were observed for the cohort and underground workers with increased time since first hire, for those hired during early periods of operation and for those with longer durations of employment. Further aetiological study is required as occupational aetiology could not be ascertained.