METABOLISM OF METHYL MERCURY (203HG) COMPOUNDS IN MAN - EXCRETION AND DISTRIBUTION
METABOLISM OF METHYL MERCURY (203HG) COMPOUNDS IN MAN - EXCRETION AND DISTRIBUTION
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DOI：
10.1080/00039896.1969.10666872
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发表时间：
1969-01-01
期刊：
影响因子：
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通讯作者：
SNIHS, JO
中科院分区：
文献类型：
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作者：
ABERG, B;EKMAN, L;SNIHS, JO
3名37至44岁的临床健康白人男性志愿者口服2.6μCi硝酸甲基汞汞203，导致203hg在肝脏和头部积聚。主要的排泄途径是粪便，但随着时间的推移尿排泄增加，直到摄入后30天。生物半衰期经全身测量发现为70至74天。头部中203hg的下降速度比身体其他部位要慢。精子中检测到No203Hg。在红细胞中发现摄取非常迅速。主要的活性集中在肝脏（约占全身含量的50%），而头部约占全身含量的10%。在无限时间后，每周单位剂量的硝酸甲基汞汞203将导致15.2单位汞的全身负荷。
The oral intake of 2.6μCi of methyl-mercuric nitrate Hg 203 by three clinically healthy, white, male volunteers aged 37 to 44 years resulted in an accumulation in the liver and the head of the203Hg. The main excretory route was the feces but the urinary excretion increased with time up to 30 days after the intake. The biological half-life was found with whole body measurements to be 70 to 74 days. The decline of203Hg in the head was less rapid than in the rest of the body. No203Hg was found in the sperm. A very rapid uptake was found in the erythrocytes. The main activity was localized in the liver (about 50% of the contents of the body) whereas the head contained about 10% of the total body content. After infinite time a weekly unit dose of methyl mercuric nitrate Hg 203 will result in a whole body burden of 15.2 units mercury.