A case in a child of giant left-atrial myxoma associated with recurrent high fever and myxoma cells expressing interleukin-6
A case in a child of giant left-atrial myxoma associated with recurrent high fever and myxoma cells expressing interleukin-6
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DOI：
10.1007/s00431-005-0061-4
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发表时间：
2006-05-01
影响因子：
3.6
通讯作者：
Hamaoka, K
中科院分区：
文献类型：
--
作者：
Shiraishi, I;Yamagishi, M;Hamaoka, K
1例6岁女童出现间歇性高烧和全身乏力2个月。入院时，白细胞计数正常(5700/mm3，嗜酸性粒细胞占3.0%)，但C反应蛋白水平升高(6.6 mg/dl)。超声心动图发现她有一个巨大的左房肿瘤(40×25×25 mm)。由于肿瘤几乎阻塞了左心室流入道，因此进行了紧急手术切除。肿瘤附着于起源于房间隔后尾缘的椎弓根(图1a)。组织病理学检查证实肿瘤组织起源于左心房壁(图1b)。星状细胞、梭形细胞和单核细胞包埋在丰富的嗜酸性基质中，与心脏粘液瘤相容(图1c)。免疫组织化学研究表明，大多数
A 6-year-old girl had intermittent high fever and general fatigue for 2 months. On admission, white blood cell count was normal (5,700/mm3 with 3.0% eosinophils) but C-reactive protein level was elevated (6.6 mg/dl). She was found to have a giant left-atrial tumor (40× 25× 25 mm) by echocardiography. Because the tumor almost obstructed the inflow tract of the left ventricle, an emergency surgical resection was carried out. The tumor was attached to a pedicle that originated from the posterior-caudal margin of the atrial septum (Fig. 1 a). Histopathological findings confirmed that the tumor tissue originated from the left-atrial wall (Fig. 1 b). Stellate cells, fusiform cells, and mononuclear cells were embedded within an abundant eosinophilic matrix, compatible with cardiac myxoma (Fig. 1 c). Immunohistochemical study demonstrated that the majority of