Osteopontin-deficiency suppresses growth of B16 melanoma cells implanted in bone and osteoclastogenesis in co-cultures
Osteopontin-deficiency suppresses growth of B16 melanoma cells implanted in bone and osteoclastogenesis in co-cultures
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DOI：
10.1359/jbmr.2004.19.10.1706
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发表时间：
2004-10-01
影响因子：
6.2
通讯作者：
Noda, M
中科院分区：
文献类型：
--
作者：
Ohyama, Y;Nemoto, H;Noda, M
肿瘤的转移和侵袭骨是现代社会的主要医学问题之一。基于敲除小鼠研究的骨桥蛋白缺乏降低肿瘤在骨中的侵袭。在骨中，骨桥蛋白是增加肿瘤侵袭的积极因素。
Tumor metastasis and invasion to bone is one of major medical issues in our modern societies. Osteopontin deficiency decreased tumor invasion in bone based on knockout mouse study. In bone, osteopontin is a positive factor to increase tumor invasion.