The tangled circuitry of metabolism and apoptosis.
The tangled circuitry of metabolism and apoptosis.
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DOI：
10.1016/j.molcel.2012.12.026
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发表时间：
2013-02-07
期刊：
影响因子：
16
通讯作者：
Kornbluth, Sally
中科院分区：
文献类型：
--
作者：
Andersen, Joshua L.;Kornbluth, Sally
对于单细胞生物来说，营养吸收和代谢是决定其生长还是分裂的最基本决定的关键。在后生动物中，细胞命运的决定更为复杂：必须通过平衡细胞增殖和死亡来严格维持生物体的稳态。尽管增加了复杂性，多细胞生物内的细胞命运也受到代谢的影响；最近的研究，部分是由对肿瘤代谢的兴趣引起的，开始阐明增殖、死亡和代谢相互交织的机制。特别是，对Bcl-2家族蛋白的研究表明，控制代谢和凋亡的信号通路是密不可分的。在这里，我们回顾了这些通路之间的串扰，强调了最近的工作，说明了几个核心凋亡蛋白在调节代谢和细胞死亡方面的双重性质。
For single cell organisms, nutrient uptake and metabolism are at the crux of their most basic decision of whether to grow or divide. In metazoans, cell fate decisions are more complex: organismal homeostasis must be strictly maintained by balancing cell proliferation and death. Despite this increased complexity, cell fate within multicellular organisms is also influenced by metabolism; recent studies, triggered in part be an interest tumor metabolism, are beginning to illuminate the mechanisms through which proliferation, death, and metabolism are intertwined. In particular, work on Bcl-2 family proteins suggests that the signaling pathways governing metabolism and apoptosis are inextricably linked. Here, we review the crosstalk between these pathways, emphasizing recent work that illustrates the emerging dual nature of several core apoptotic proteins in regulating both metabolism and cell death.
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