Quadripulse stimulation - A new patterned rTMS
Quadripulse stimulation - A new patterned rTMS
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DOI：
10.3233/rnn-2010-0564
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发表时间：
2010-01-01
影响因子：
2.8
通讯作者：
Ugawa, Yoshikazu
中科院分区：
文献类型：
--
作者：
Hamada, Masashi;Ugawa, Yoshikazu
一种新的模式化重复经颅磁刺激（rTMS）协议，四脉冲刺激（QPS），可以产生广泛的运动皮层可塑性，范围从MEP抑制到MEP促进，这取决于脉冲串内的脉冲间隔。除了诱导持久的皮质可塑性变化外，QPS还可用于评估启动效应：当用作启动刺激时，其本身不会诱导LTP或LTD样现象，但它可以改变由连续刺激引起的LTP或LTD样可塑性的阈值。这使我们能够在人类中更详细地研究变形性理论。QPS的另一个应用可能是诱导神经或精神疾病患者的症状缓解，如帕金森病，抑郁症或顽固性疼痛。
A new patterned repetitive transcranial magnetic stimulation (rTMS) protocol, quadripulse stimulation (QPS), can produce a broad range of motor cortical plasticity ranging from MEP suppression to MEP facilitation depending on the interval of the pulses within a burst. In addition to inducing lasting cortical plastic changes, QPS can also be used to evaluate priming effects: when used as a priming stimulation, which does not induce an LTP- or LTD-like phenomena itself, it can nevertheless change the threshold for LTP- or LTD-like plasticity caused by a consecutive stimulation. This enables us to examine metaplasticity theory in more details in humans. Another application of QPS might be to induce symptomatic relief in patients with neurological or psychiatric disorders, such as Parkinson's disease, depression, or intractable pain.