Voltage-Gated Intrinsic Conductances Shape the Input-Output Relationship of Cortical Neurons in Behaving Primate V1.
Voltage-Gated Intrinsic Conductances Shape the Input-Output Relationship of Cortical Neurons in Behaving Primate V1.
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DOI：
10.1016/j.neuron.2020.04.001
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发表时间：
2020-07-08
期刊：
影响因子：
16.2
通讯作者：
Priebe, Nicholas J.
中科院分区：
文献类型：
--
作者：
Li, Baowang;Routh, Brandy N.;Johnston, Daniel;Seidemann, Eyal;Priebe, Nicholas J.
神经元是输入-输出（I/O）设备-它们从其他神经元接收突触输入，将这些输入与它们的内在属性相结合，并产生动作电位作为输出。为了理解这一基本过程，我们研究了突触输入和内在属性之间的相互作用，使用清醒的，固定猕猴的V1神经元的全细胞记录。我们在自发活动和视觉刺激过程中的测量揭示了一种内在的电压门控电导，它深刻地改变了皮层神经元的综合特性和视觉反应。这种电压门控电导通过阈下去极化增加神经元的增益和选择性，并使突触输入和神经输出之间的关系线性化。这种内在电导在清醒猕猴、麻醉小鼠和急性脑切片的第2/3层V1神经元中发现。这些结果表明，内在电导在塑造皮层神经元的I/O关系中起着至关重要的作用，必须考虑到在未来的模型的皮层计算。Li等人使用全细胞记录揭示了一个大的和意想不到的电压门控的内在电导，大大改变了灵长类动物V1神经元的整合特性。因此，一个标准的计算模型的感觉神经元，包括线性整合的突触输入，其次是阈值非线性需要修订。
Neurons are input-output (I/O) devices—they receive synaptic inputs from other neurons, integrate those inputs with their intrinsic properties, and generate action potentials as outputs. To understand this fundamental process, we studied the interaction between synaptic inputs and intrinsic properties using whole-cell recordings from V1 neurons of awake, fixating macaque monkeys. Our measurements during spontaneous activity and visual stimulation reveal an intrinsic voltage-gated conductance that profoundly alters the integrative properties and visual responses of cortical neurons. This voltage-gated conductance increases neuronal gain and selectivity with subthreshold depolarization and linearizes the relationship between synaptic input and neural output. This intrinsic conductance is found in layer 2/3 V1 neurons of awake macaques, anesthetized mice, and acute brain slices. These results demonstrate that intrinsic conductances play an essential role in shaping the I/O relationship of cortical neurons and must be taken into account in future models of cortical computations. Li et al. used whole-cell recording to reveal a large and unexpected voltage-gated intrinsic conductance that dramatically alters the integrative properties of primate V1 neurons. Therefore, a standard computational model of sensory neurons that incorporates linear integration of synaptic inputs followed by a threshold nonlinearity requires revision.
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