Validation of an adapted MRI pulse sequence for quantification of fatty infiltration in muscle
Validation of an adapted MRI pulse sequence for quantification of fatty infiltration in muscle
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DOI：
10.1016/j.mri.2009.01.009
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发表时间：
2009-07-01
影响因子：
2.5
通讯作者：
Chenevert, Thomas L.
中科院分区：
文献类型：
--
作者：
Doro, Lisa Case;Ladd, Bryan;Chenevert, Thomas L.
目的：我们研究的长期目标是建立一个患者特异性冈上肌和肌腱的生物力学模型，用于分析脂肪浸润和羽状角变化的影响。模型的一个输入将是肌肉内脂肪的数量和分布。因此，本项目的目的是适应和验证一种新的磁共振成像脉冲序列的脂肪浸润的程度进行量化的冈上肌muscle.Methods：从牛的肌肉和脂肪的增量组合的样品制备和扫描与我们的定量MR技术。MR结果进行了比较，以实际脂肪测量使用Soxtec提取analyzer.Results：MR脂肪定量结果密切匹配的值确定的Soxtec分析（R-2 = 0.98，均方根偏差= 4.9）。结论：我们的MR脂肪定量协议可以用来准确地量化脂肪浸润骨骼肌。这种非侵入性评估骨骼肌组织的能力将提高术前评估组织质量中脂肪变性评估的有效性。这在任何肌肉骨骼修复的手术计划中都很重要，特别是肩袖撕裂。(C)2009爱思唯尔公司All rights reserved.
Purpose: The long-term goal of our research is to develop a patient-specific biomechanical model of the supraspinatus muscle and tendon for analyzing the effects of fatty infiltration and pennation angle changes. One input of the model will be the amount and distribution of fat within the muscle. Therefore, the objective of this project was to adapt and validate a novel magnetic resonance imaging pulse sequence for quantifying the extent of fatty infiltration for the supraspinatus muscle.Methods: Samples of incremental combinations of muscle and fat from a cow were prepared and scanned with our quantitative MR technique. The MR results were compared to actual fat measurements taken using a Soxtec extraction analyzer.Results: The MR fat quantification results closely match those values determined by Soxtec analysis (R-2 = .98, root mean square deviation = 4.9).Conclusions: Our MR fat quantification protocol can be used to accurately quantify fatty infiltration in skeletal muscle. This ability to evaluate skeletal muscle tissue noninvasively will improve the efficacy of evaluation of fatty degeneration in assessing tissue quality preoperatively. This can be important in surgical planning of any musculoskeletal repairs, particularly rotator cuff tears. (C) 2009 Elsevier Inc. All rights reserved.