Co‐production of microbial lipids with valuable chemicals
Co‐production of microbial lipids with valuable chemicals
复制标题
DOI：
10.1002/bbb.2209
复制
发表时间：
2021-03
期刊：
影响因子：
--
通讯作者：
Lin Chen;Xiujuan Qian;Xiaoyu Zhang;Xinhai Zhou;Jie Zhou;W. Dong;F. Xin;Wenming Zhang;M. Jiang;K. Ochsenreither
中科院分区：
文献类型：
--
作者：
Lin Chen;Xiujuan Qian;Xiaoyu Zhang;Xinhai Zhou;Jie Zhou;W. Dong;F. Xin;Wenming Zhang;M. Jiang;K. Ochsenreither
微生物脂是石油和植物油的有前途的替代品。然而，微生物油脂的工业化发展仍然有限，由于其生产成本较高，无法与石化石油相抗衡。能够积累脂质和其他有价值的化学物质的微生物对提高微生物脂质生产过程的经济性具有吸引力。与增加复杂代谢工程的产量以提高整体经济相比，多化学物质协同生产系统在平衡代谢通量和优化细胞生理恢复方面更有利。在这篇综述中，根据它们的细胞位置对与微生物脂质共同产生的各种化学物质进行了分类。有效的策略，包括发酵过程和基因工程调节和加强这种合作生产系统，全面讨论。强调了油脂和贵重化学品协同生产过程规模化的前景和挑战。©2021化学工业协会和约翰威利父子有限公司
Microbial lipids are promising substitutes for petroleum and plant oil. However, the industrialization of microbial lipids is still limited and cannot compete with petrochemical petroleum due to its high production cost. Microorganisms capable of accumulating lipids and additional valuable chemicals are attractive for improving the economics of the microbial lipid production process. Compared with the increase in production of complex metabolic engineering to improve the overall economy, the multi‐chemical co‐production system is more advantageous in balancing the metabolic flux and optimal cell physiological recovery. In this review, various chemicals co‐produced with microbial lipids are classified according to their cell location. Efficient strategies, including the fermentation process and genetic engineering for regulating and enhancing such co‐production systems, are comprehensively discussed. The prospective and challenges during the scale‐up of lipids and valuable chemicals co‐production process are also highlighted. © 2021 Society of Chemical Industry and John Wiley & Sons, Ltd