Osteogenic Repair by Bovine Bone Ash Derived Porous HA Ceramic Formed by Foaming Method
Osteogenic Repair by Bovine Bone Ash Derived Porous HA Ceramic Formed by Foaming Method
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DOI：
10.4028/www.scientific.net/kem.342-343.633
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发表时间：
2007-07
期刊：
影响因子：
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通讯作者：
J. Yoon;J.H. Park;E. Park;Shin-Yoon Kim;J.H. Lee;I. Park;H.J. Kim;Hong-In Shin
中科院分区：
文献类型：
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作者：
J. Yoon;J.H. Park;E. Park;Shin-Yoon Kim;J.H. Lee;I. Park;H.J. Kim;Hong-In Shin
为了开发一种合适的支架优化骨再生，我们开发了牛骨灰衍生的全连接多孔HA陶瓷支架，采用发泡法。它们显示出优异的生物相容性。贴壁细胞呈多层增殖，并向成骨细胞分化。结果表明，以牛骨灰为原料制备的完全互连多孔HA陶瓷（平均球形孔尺寸为500 μm，平均互连孔尺寸为150 μm，平均孔隙率为80%）移植骨缺损3周内愈合良好，无任何病理变化。从植入后1周开始，观察到新骨长入，并沿内表面沿着通过球形孔进行良好的骨传导。每个球形孔充满造血骨髓和新形成的骨，随着时间的推移，新形成的骨与多孔HA陶瓷支架很好地结合。这些结果表明，发泡法制备的牛骨灰源性完全互连多孔HA陶瓷是一种很有前途的骨替代材料和骨组织工程支架材料。
To develop a suitable scaffold optimizing bone regeneration, we developed bovine bone ash derived fully connected porous HA ceramic scaffolds adopting a foaming method. They revealed excellent biocompatibility. The attached cells on the scaffolds proliferated in multi-layers with osteoblastic differentiation. The bone defects grafted with bovine bone ash derived fully interconnected porous HA ceramics having average 500 μm sized spherical pores and average 150 μm sized interconnecting interpores with average 80% porosity were favorably healed without any pathologic changes within 3 weeks. New bone ingrowth with excellent osteoconduction through the spherical pores along the inner surface was noted from 1 week after implantation. Each spherical pore was filled with hematopoietic marrow and newly formed bone which with time was well integrated with the porous HA ceramic scaffold with time. These findings suggest that the bovine bone ash-derived fully interconnected porous HA ceramic formed by foaming method can be a promising bone substitute and a scaffold for bone tissue engineering.