Prediction and design of macromolecular structures and interactions
Prediction and design of macromolecular structures and interactions
复制标题
DOI：
10.1098/rstb.2005.1803
复制
发表时间：
2006-03-29
影响因子：
6.3
通讯作者：
Baker, D
中科院分区：
文献类型：
--
作者：
Baker, D
在这篇文章中，我总结了我的小组最近的工作，致力于开发一个改进的模型内和分子间的相互作用，并将此改进的模型应用于预测和设计的大分子结构和相互作用。预测和设计应用程序本身就具有很大的生物学意义，并且还提供非常严格和客观的测试，这些测试推动了模型的改进并增加了基本的理解。我强调预测和设计测试的结果，这些结果表明在高分辨率建模方面正在取得进展，并且有希望可靠和准确地计算结构生物学。
In this article, I summarize recent work from my group directed towards developing an improved model of intra and intermolecular interactions and applying this improved model to the prediction and design of macromolecular structures and interactions. Prediction and design applications can be of great biological interest in their own right, and also provide very stringent and objective tests which drive the improvement of the model and increases in fundamental understanding. I emphasize the results from the prediction and design tests that suggest progress is being made in high-resolution modelling, and that there is hope for reliably and accurately computing structural biology.