Human herpesvirus 8 seroprevalence among prostate cancer case patients and control subjects
Human herpesvirus 8 seroprevalence among prostate cancer case patients and control subjects
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DOI：
10.1086/518790
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发表时间：
2007-07-15
影响因子：
6.4
通讯作者：
Goedert, J. J.
中科院分区：
文献类型：
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作者：
Jenkins, F. J.;Hayes, R. B.;Goedert, J. J.
为了研究人类疱疹病毒8型(HHV-8)与前列腺癌之间的可能联系，我们在2个病例对照研究中评估了HHV-8血清阳性率。用表达裂解病毒蛋白的细胞免疫荧光法检测HHV-8抗体，用重组病毒结构蛋白(K8.1)和潜伏蛋白(潜伏相关核抗原-1；开放阅读框73)检测HHV-8抗体。前列腺癌患者的HHV-8血清阳性率倾向于低于对照组，但在两项研究中都没有显著差异。这些数据表明，HHV-8不是前列腺癌的主要流行原因。
To investigate a possible association between human herpesvirus 8 ( HHV- 8) and prostate cancer, we evaluated HHV-8 seroprevalence in 2 case- control studies. HHV- 8 antibodies were detected by immunofluorescence with cells expressing lytic viral proteins and by enzyme immunoassays with recombinant viral structural protein ( K8.1) and latent protein ( latency- associated nuclear antigen - 1; open reading frame 73), respectively. HHV- 8 seroprevalence tended to be lower in patients with prostate cancer than in control subjects, but there was no significant difference in either study. These data imply that HHV- 8 is not a major prevalent cause of prostate cancer.