Anatomical brain difference of subthreshold depression in young and middle-aged individuals.
Anatomical brain difference of subthreshold depression in young and middle-aged individuals.
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DOI：
10.1016/j.nicl.2017.02.022
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Kong J
中科院分区：
文献类型：
--
作者：
Li J;Wang Z;Hwang J;Zhao B;Yang X;Xin S;Wang Y;Jiang H;Shi P;Zhang Y;Wang X;Lang C;Park J;Bao T;Kong J
阈下抑郁 (StD) 与由于抑郁症状不完全符合重度抑郁症 (MDD) 的诊断而导致的严重功能障碍相关。它在普通人群中的高发病率和令人衰弱的症状最近使其成为情绪障碍研究的前沿。在这项研究中，我们调查了年轻和中年 STD 患者常见的大脑体积变化。两组 STD 患者（年轻和中年）（n = 57）和匹配对照（n = 76）接受了基于体素的形态测量（VBM）。 VBM分析发现：1）与健康对照相比，StD患者双侧苍白球和中央前回灰质体积（GMV）减少，左侧丘脑和右侧头侧前扣带皮层/内侧前额叶皮质GMV增加； 2）流行病学研究中心抑郁量表评分与双侧苍白球（阴性）和左侧丘脑（阳性）之间存在显着相关性； 3）年龄（年轻与中年）和群体（标准与对照组）之间不存在交互作用。我们的研究结果表明，患有性病的年轻和中年个体的 VBM 大脑发生了显着变化。患有性病的人，无论年龄大小，都可能有共同的神经特征。年轻的 STD 个体的解剖学变化。老StD个体的解剖学变化。年轻和中年 STD 个体的共同神经特征。
Subthreshold depression (StD) is associated with substantial functional impairments due to depressive symptoms that do not fully meet the diagnosis of major depressive disorder (MDD). Its high incidence in the general population and debilitating symptoms has recently put it at the forefront of mood disorder research. In this study we investigated common volumetric brain changes in both young and middle-aged StD patients. Two cohorts of StD patients, young and middle-aged, (n = 57) and matched controls (n = 76) underwent voxel-based morphometry (VBM). VBM analysis found that: 1) compared with healthy controls, StD patients showed decreased gray matter volume (GMV) in the bilateral globus pallidus and precentral gyrus, as well as increased GMV in the left thalamus and right rostral anterior cingulate cortex/medial prefrontal cortex; 2) there is a significant association between Center for Epidemiological Studies Depression Scale scores and the bilateral globus pallidus (negative) and left thalamus (positive); 3) there is no interaction between age (young vs. middle-age) and group (StD vs. controls). Our findings indicate significant VBM brain changes in both young and middle-aged individuals with StD. Individuals with StD, regardless of age, may share common neural characteristics. The anatomical changes in the young StD individuals. The anatomical changes in the old StD individuals. The common neural characteristics in both young and middle-aged individuals with StD.