Substantivity of toothpaste slurries and their effect on reestablishment of the dental biofilm
Substantivity of toothpaste slurries and their effect on reestablishment of the dental biofilm
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DOI：
10.1034/j.1600-051x.2002.290705.x
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发表时间：
2002-07-01
影响因子：
6.7
通讯作者：
Netuschil, L
中科院分区：
文献类型：
--
作者：
Arweiler, NB;Auschill, TM;Netuschil, L
目的：牙膏是抗菌物质发挥长期作用的良好载体。这种效果取决于干扰斑块代谢和/或活力的实质性和能力。这项临床、随机 2 x 4 细胞交叉研究的目的是评估和比较两种牙膏（高露洁 Total(R)、COL 和 Parodontax(R)、PAR）作为牙膏在 24 小时内对已形成的牙菌斑施用的抗菌效果（第一部分）以及它们对 4 天牙菌斑再生的影响（第二部分）。 Chlorhexamed(R)（0.1%；CHX）和水作为阳性和阴性对照。材料和方法：在专业牙齿清洁后，要求八名学生在接下来的 72 小时内避免采取所有机械卫生措施。 48小时后，对菌斑进行取样并检查菌斑菌群的活力（基线，VF0%）。然后受试者用 15 mL 的一种测试或对照溶液冲洗 1 分钟。冲洗后每隔一小时直至 14 小时和 24 小时，进行菌斑取样和染色以评估菌斑活力（VF2-24，第一部分）。在第二部分中，采用经典的 4 天牙菌斑再生设计，每天两次漱口（1 分钟），作为唯一的口腔卫生措施。在第 1 天和第 4 天评估活力值（VF1、VF2）。第 4 天，对牙齿进行染色，以评估全口牙菌斑指数 (PlI) 并评估前牙的牙菌斑面积 (PA) 百分比。 结果：与安慰剂相比，所有主动漱口水在 24 小时内均显着降低牙菌斑活力（第一部分）。 PAR、COL 和 CHX 分别减少了 18-31%、28-50% 和 19-50%。在第二部分中，发现所有活性冲洗液的所有参数都有类似的降低（PAR 12-30%、COL 34-51%、CHX 40-64%）。结论：高露洁全效对牙菌斑再生具有显着作用，并且在 24 小时内具有高显着效果，而 Parodontax 则显示出更温和但仍然显着的效果。
Objectives: Toothpastes are good vehicles for antibacterial substances to exert a prolonged effect. This effect depends on the substantivity and ability to interfere with plaque metabolism and/or vitality. It was the purpose of this clinical, randomized 2 x 4 cell crossover study to evaluate and to compare the antibacterial effects of two toothpastes (Colgate Total(R), COL and Parodontax(R), PAR) applied as slurries on established plaque over 24 h (Part I) and their effect on 4-day plaque regrowth (Part II). Chlorhexamed(R) (0.1%; CHX) and water served as positive and negative controls.Material and methods: After professional toothcleaning eight students were asked to refrain from all mechanical hygiene measures for the next 72 h. After 48 h plaque was sampled and vitality of the plaque flora examined (baseline, VF0 %). The subjects then rinsed for 1 min with 15 mL of one of the test or control solutions. Every second hour up to 14 h and 24 h after rinsing, plaque sampling and staining was performed to assess plaque vitality (VF2-24 , Part I). In Part II, the classical 4-day plaque regrowth design was used with two rinses (1 min) a day as the only oral hygiene measure. Vitality values were assessed on day 1 and day 4 (VF1, VF2). At day 4, teeth were stained to assess the whole mouth plaque index (PlI) and to evaluate the percentage of plaque area (PA) of the anterior teeth.Results: Compared to placebo, all active rinses reduced plaque vitality significantly over a period of 24 h (Part I). PAR, COL and CHX revealed reductions of 18-31%, 28-50% and 19-50%, respectively. In Part II, similar reductions of all parameters were found for all active rinses (PAR 12-30%, COL 34-51%, CHX 40-64%).Conclusions: Colgate Total has shown a significant action on plaque regrowth and a high substantivity during 24 h, while Parodontax revealed a more moderate but still significant effect.