Introducing Ligand-Based Hydrogen Bond Donors to a Receptor: Both Selectivity and Binding Affinity for Anion Recognition in Water Can Be Improved
Introducing Ligand-Based Hydrogen Bond Donors to a Receptor: Both Selectivity and Binding Affinity for Anion Recognition in Water Can Be Improved
复制标题
将基于配体的氢键供体引入受体：可以提高水中阴离子识别的选择性和结合亲和力
DOI：
10.1021/jo302271t
复制
发表时间：
2012-12-21
影响因子：
3.6
通讯作者：
Feng, Guoqiang
中科院分区：
文献类型：
--
作者：
Huang, Feihu;Cheng, Chen;Feng, Guoqiang
在受体上引入氢键供体是提高其对焦磷酸盐选择性和亲和力的有效途径。Zn_3-ADP复合物的晶体结构表明，这种改进来自于氢键和金属配位的结合，其方式类似于许多金属酶。
Introducing hydrogen bond donors to a receptor was found to be an effective approach to improve both its selectivity and binding affinity for pyrophosphate in water. The crystal structure of Zn3-ADP complex showed the improvements come from the combination of H-bonding and metal coordination in a manner similar to many metalloenzymes.