Effects of rutin and its derivatives on citrinin production by Monascus aurantiacus Li AS3.4384 in liquid fermentation using different types of media
Effects of rutin and its derivatives on citrinin production by Monascus aurantiacus Li AS3.4384 in liquid fermentation using different types of media
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芦丁及其衍生物对不同类型培养基液体发酵中橙红曲霉Li AS3.4384产生桔霉素的影响
DOI：
10.1016/j.foodchem.2019.01.109
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发表时间：
2019-06-30
期刊：
影响因子：
8.8
通讯作者：
Huang, Ting
中科院分区：
文献类型：
--
作者：
Huang, Zhibing;Zhang, Lijuan;Huang, Ting
真菌毒素桔霉素通常在蒙地诺产品的发酵过程中产生。我们通过向发酵培养基中添加芦丁、α-葡糖基芦丁或曲克芦丁，研究了黄酮类化合物对Monacolaurantiacus Li AS 3.4384（MALA）桔霉素生产的影响。适量的芦丁，α-葡糖基芦丁，或曲克赛灵不影响正常的菌丝生长。相对于5 g/l α-葡糖基芸香苷或曲克塞鲁肽的抑制作用（分别为54.7%和40.6%），添加5.0 g/l芸香苷仅微弱地降低（29.2%）桔霉素的产生。在淀粉无机液体培养基中，添加20.0g/L曲克赛灵，发酵12 d，桔霉素产量下降75.26%。在低淀粉蛋白胨液体发酵培养基中添加15.0 g/l的曲克赛灵，发酵14 d后桔霉素产量下降87.9%，在酵母膏蔗糖液体培养基中添加30.0 g/l的曲克赛灵，发酵12 d后桔霉素产量下降53.7%。
The mycotoxin citrinin is often produced during fermentation of Monascus products. We studied the effects of flavonoids on citrinin production by Monascus aurantiacus Li AS3.4384 (MALA) by adding rutin, alpha-glucosylrutin, or troxerutin to the fermentation medium, in a first-of-its-kind study. Appropriate amounts of rutin, alpha-glucosylrutin, or troxerutin did not affect normal mycelial growth. Addition of 5.0 g/l of rutin only weakly reduced (29.2%) citrinin production, relative to inhibition by 5 g/l alpha-glucosylrutin or troxerutin (by 54.7% and 40.6%, respectively). In starch inorganic liquid culture media, addition of 20.0 g/l of troxerutin, followed by fermentation for 12 days, reduced citrinin yield by 75.26%. Addition of 15.0 g/l of troxerutin to low-starch peptone liquid fermentation media reduced citrinin yield by 87.9% after 14 days of fermentation, and addition of 30.0 g/l troxerutin to yeast extract sucrose liquid media for 12 days reduced citrinin yield by 53.7%.