Obstetric conditions and risk of first admission with schizophrenia: A Danish national register based study
Obstetric conditions and risk of first admission with schizophrenia: A Danish national register based study
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DOI：
10.1016/j.schres.2007.07.018
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发表时间：
2007-12-01
影响因子：
4.5
通讯作者：
Mortensen, Preben Bo
中科院分区：
文献类型：
--
作者：
Byrne, Majella;Agerbo, Esben;Mortensen, Preben Bo
一系列妊娠并发症、胎儿生长发育异常和分娩并发症与精神分裂症风险增加有关。很少有研究能够调整广泛的潜在混杂因素。一项基于丹麦纵向登记的全国人群巢式病例对照研究旨在调查与暴露于一系列产科事件相关的精神分裂症风险。样本包括1039名首次入院或与丹麦精神病服务机构联系的ICD-8或ICD-10诊断为精神分裂症的患者和24826名个体匹配的对照组。调整其他产科因素、家族精神病史、社会经济和人口统计学因素后，精神分裂症的风险与母亲不参加产前检查有关（发病率比（IRR）2.08，95% CI：1.0，4.4），胎龄3 - 7周或以下（IRR 1.51，95% CI：1.0，2.2），母体流感（IRR 8.2，95% CI：1.4，48.8），先兆子痫（IRR 2.72，95% CI：1.0，7.3），先兆早产（IRR 2.39，95% CI：1.4，4.1），分娩期间出血（IRR 2.43，95% CI：1.1，5.6），婴儿手动拔除（IRR 2.15，95% CI：1.1，4.4），以及分娩和产褥期的母体败血症（IRR 2.91，95% CI：1.1，7.9）。产科因素与性别或家族精神病史之间无显著交互作用。这些数据表明，在调整了一些可能的混杂因素后，早产、缺氧指标、母体感染和母体行为与以后发展为精神分裂症的风险之间存在适度的相关性。(c)2007年由Elsevier B. V.出版。
A range of complications of pregnancy, abnormal fetal growth and development, and complications of delivery have been associated with increased risk of schizophrenia. Few studies have been able to adjust for a broad range of potential confounding factors. A national population nested case-control study based on Danish longitudinal registers was conducted to investigate the risk of schizophrenia associated with exposure to a range of obstetric events. The sample included 1039 first admissions to, or contacts with Danish psychiatric services with an ICD-8 or ICD-10 diagnosis of schizophrenia and 24, 826 individually matched controls. Adjusting for the other obstetric factors, family psychiatric history, and socio-economic and demographic factors, risk of schizophrenia was associated with maternal non-attendance at antenatal appointments (Incidence Rate Ratio (IRR) 2.08, 95% CI: 1.0, 4.4), gestational age of 3 7 weeks or below (IRR 1.51, 95% CI: 1.0, 2.2), maternal influenza (IRR 8.2, 95% CI: 1.4,48.8), preeclampsia (IRR 2.72, 95% CI: 1.0, 7.3), threatened premature delivery (IRR 2.39, 95% CI: 1.4, 4.1), haemorrhage during delivery (IRR 2.43, 95% CI: 1.1, 5.6), manual extraction of the baby (IRR 2.15, 95% CI: 1.1, 4.4), and maternal sepsis of childbirth and the puerperium (IRR 2.91, 95% CI: 1.1, 7.9). There was no significant interaction between the obstetric factors and either sex or family psychiatric history. The data suggest a modest association between prematurity, indicators of hypoxia, maternal infections, and maternal behaviours and risk of the later development of schizophrenia after adjusting for a number of possible confounding factors. (c) 2007 Published by Elsevier B.V.