Increase of brain oxidative stress in mild cognitive impairment -: A possible predictor of Alzheimer disease
Increase of brain oxidative stress in mild cognitive impairment -: A possible predictor of Alzheimer disease
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DOI：
10.1001/archneur.59.6.972
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发表时间：
2002-06-01
影响因子：
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通讯作者：
Trojanowski, JQ
中科院分区：
文献类型：
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作者：
Praticò, D;Clark, CM;Trojanowski, JQ
背景：异前列腺素8,12-iso- ipf (2alpha)-VI是体内脂质过氧化的特异性标志物，在阿尔茨海默病（AD）中升高。与AD相关的病理改变在临床症状出现之前有很长的沉默期。一些研究表明，阿尔茨海默病之前有一个以轻度认知障碍（MCI）为特征的前驱期。目的：探讨MCI患者中该生物标志物的水平。设计和主要结果测量：采用气相色谱-质谱分析，我们测量了AD患者、MCI患者和认知正常的老年受试者尿液、血浆和脑脊液中的8,12-iso- ipf (2alpha)-VI水平。环境和患者：参加记忆障碍诊所的受试者。结果：我们发现MCI患者脑脊液、血浆和尿液中的8,12- isoipf (2alpha)-VI水平明显高于认知正常的老年受试者。结论：这些结果表明，轻度认知损伤患者在症状性痴呆发病前脑氧化损伤增加。这种异前列腺素的测量可以识别出MCI患者中脂质过氧化升高的亚组，这些患者进展为症状性AD的风险增加。
Background: The isoprostane 8,12-iso-iPF(2alpha)-VI, a specific marker of in vivo lipid peroxidation, is increased in Alzheimer disease (AD). The pathological changes associated with AD have a long silent phase before the appearance of clinical symptoms. Several studies have shown that AD is preceded by a prodromal phase characterized by mild cognitive impairment (MCI).Objective: To investigate levels of this biomarker in subjects with MCI.Design and Main Outcome Measures: Using gas chromatography-mass spectrometry analysis, we measured 8,12-iso-iPF(2alpha)-VI levels in urine, plasma, and cerebrospinal fluid of patients with AD, subjects with MCI, and cognitively normal elderly subjects.Setting and Patients: Subjects attending the Memory Disorders Clinic.Results: We found significantly higher 8,12-isoiPF(2alpha)-VI levels in cerebrospinal fluid, plasma, and urine of subjects with MCI compared with cognitively normal elderly subjects.Conclusions: These results imply that individuals with MCI have increased brain oxidative damage before the onset of symptomatic dementia. Measurement of this isoprostane may identify a subgroup of patients with MCI with increased lipid peroxidation who are at increased risk to progress to symptomatic AD.