Usefulness of increased skin cholesterol to identify individuals at increased cardiovascular risk (from the predictor of advanced subclinical atherosclerosis study)
Usefulness of increased skin cholesterol to identify individuals at increased cardiovascular risk (from the predictor of advanced subclinical atherosclerosis study)
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DOI：
10.1016/j.amjcard.2007.11.044
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发表时间：
2008-04-01
影响因子：
2.8
通讯作者：
Davidson, Michael H.
中科院分区：
文献类型：
--
作者：
Stein, James H.;Tzou, Wendy S.;Davidson, Michael H.
在有症状的冠心病患者中，皮肤胆固醇（SC）含量与冠状动脉疾病的存在和程度相关；然而，其与无症状患者亚临床动脉疾病的关系尚不清楚。本研究的目的是确定在广泛的心血管危险的无症状受试者中SC与颈动脉内膜-中膜厚度（CIMT）之间的关系。SC采用无创法测定。采用高分辨率b超检测颈动脉斑块的存在。通过多变量logistic回归分析评估SC、CIMT、颈动脉斑块存在和心血管危险因素之间的关系。在北美6个地点的565名无症状受试者（57 +/- 10岁，38%女性）中测量SC和CIMT。Framingham 10年心血管风险平均值为8.4±7.2%。SC的10-U增加与CIMT增加的几率增加12% （p = 0.006）和颈动脉斑块存在增加15% （p = 0.002）相关。与颈动脉斑块相关的比值比（95%可信区间）为：CIMT增加的比值比为2.19 (1.25 ~ 3.85,p = 0.006)，颈动脉斑块存在的比值比为2.89 （1.61 ~ 5.19,p < 0.001）。总之，SC确定了晚期亚临床动脉粥样硬化的存在。SC升高、CIMT升高和颈动脉斑块存在之间的关系在所有心血管危险水平上都是一致的，并且与心血管危险因素无关。SC可能是一种有用的心血管风险预测试验。(C) 2008爱思唯尔公司
In patients with symptomatic coronary heart disease, skin cholesterol (SC) content is associated with the presence and extent of coronary artery disease; however, its relation to subclinical arterial disease in asymptomatic patients is unknown. The purpose of this study was to determine the relations between SC and carotid intima-media thickness (CIMT) in asymptomatic subjects across a wide range of cardiovascular risk. SC was measured using a noninvasive assay. CIMT and carotid plaque presence were determined by high-resolution B-mode ultrasound. Associations among SC, CIMT, carotid plaque presence, and cardiovascular risk factors were evaluated by multivariable logistic regression analyses. SC and CIMT were measured in 565 asymptomatic subjects (57 +/- 10 years of age, 38% women) from 6 sites in North America. The mean Framingham 10-year cardiovascular risk was 8.4 +/- 7.2%. A 10-U increase in SC was associated with a 12% increase in the odds of having increased CIMT (p = 0.006) and a 15% increase in carotid plaque presence (p = 0.002). Odds ratios (95% confidence intervals) associated with SC > 110 U were 2.19 (1.25 to 3.85, p = 0.006) for increased CIMT and 2.89 (1.61 to 5.19, p < 0.001) for carotid plaque presence. In conclusion, SC identified the presence of advanced subclinical atherosclerosis. The relations among increasing SC, increasing CIMT, and carotid plaque presence were consistent across all levels of cardiovascular risk and were independent of cardiovascular risk factors. SC may be a useful test for cardiovascular risk prediction. (C) 2008 Elsevier Inc.