Safety of and tolerance to adenosine infusion for myocardial perfusion single-photon emission computed tomography in a Japanese population
Safety of and tolerance to adenosine infusion for myocardial perfusion single-photon emission computed tomography in a Japanese population
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DOI：
10.1253/circj.71.904
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发表时间：
2007-06-01
影响因子：
3.3
通讯作者：
Ohe, Tohru
中科院分区：
文献类型：
--
作者：
Hatanaka, Kunihiko;Doi, Masayuki;Ohe, Tohru
背景自2005年以来，腺苷已在日本用于心肌灌注单光子发射计算机断层扫描（SPECT）。本研究的目的是评估的安全性和耐受性，以铊-201心肌灌注SPECT与静脉内腺苷输注在日本患者怀疑冠状动脉diseases.Methods和结果206例连续进行了腺苷输注（120微克中心点公斤（-1）中心点分钟（-1））SPECT在住友别志医院（新滨市，日本）进行了调查。监测每例患者的腺苷输注效果。81例患者进行了冠状动脉造影。腺苷输注显著降低血压和增加心率。161例患者（78.2%）出现不良反应。大多数反应是短暂的，在腺苷输注终止后很快消失。未发生急性心肌梗死、死亡等严重不良反应。3例（1.5%）因晕厥或持续2：1房室传导阻滞而终止腺苷输注。心电图改变15例（7.3%）。SPECT后自我评估评分显示，患者对腺苷灌注心肌SPECT非常耐受（占177例患者的74.6%）。的敏感性和特异性分别为75.0%和69.7%，force.Conclusions腺苷灌注心肌SPECT是安全的，耐受性良好，在日本人口，尽管经常发生轻微的不良反应。
Background Adenosine has been available for use in myocardial perfusion single-photon emission computed tomography (SPECT) in Japan since 2005. The purpose of this study was to evaluate the safety of and tolerance to thallium-201 myocardial perfusion SPECT with intravenous adenosine infusion in Japanese patients with suspected coronary artery disease.Methods and Results Two hundred and six consecutive patients who underwent an adenosine infusion (120 mu g center dot kg(-1) center dot min(-1)) SPECT at Sumitomo Besshi Hospital (Niihama, Japan) were investigated. The effects of adenosine infusion were monitored for each patient. A coronary angiography was performed in 81 patients. Adenosine infusion significantly decreased blood pressure and increased heart rate. Adverse reactions were observed in 161 patients (78.2%). Most reactions were transient, disappearing soon after the termination of adenosine infusion. No serious adverse reactions, such as acute myocardial infarction or death, occurred. Adenosine infusion was terminated in 3 patients (1.5%) because of near syncope or sustained 2:1 atrioventricular block. Electrocardiographic changes occurred in 15 patients (7.3%). Self-assessed scoring after SPECT showed that the patients were very tolerant (74.6% of 177 patients) of adenosine infusion myocardial SPECT. The sensitivity and specificity were 75.0% and 69.7%, respectively.Conclusions Adenosine infusion myocardial SPECT is safe and well tolerated in the Japanese population, despite the frequent occurrence of minor adverse reactions.