Resistance of vaccinia virus to interferon is related to an interference phenomenon between the virus and the interferon system.
Resistance of vaccinia virus to interferon is related to an interference phenomenon between the virus and the interferon system.
复制标题
痘苗病毒对干扰素的耐药性与病毒与干扰素系统之间的干扰现象有关。
DOI：
10.1016/0042-6822(84)90268-x
复制
发表时间：
1984
期刊：
影响因子：
3.7
通讯作者：
Esteban,M
中科院分区：
文献类型：
--
作者：
Paez,E;Esteban,M
在这项研究中，我们在培养的细胞中检查了痘苗病毒对干扰素 (IFN) 的敏感性。在多种不同来源的小鼠和人类细胞中，发现痘苗病毒功能（RNA、蛋白质和病毒产量）对干扰素相对具有抵抗力。在这些系统中，IFN介导的酶活性（2-5A合成酶和蛋白激酶）水平受到病毒的严重损害。这种病毒介导的抑制作用在感染后随着时间的推移而发展，并且依赖于病毒蛋白的合成。痘苗病毒和对IFN敏感的病毒（VSV或脊髓灰质炎）混合感染表明蛋白质合成和病毒产量均未受到抑制。这些发现表明痘苗病毒可以克服干扰素的抗病毒作用，并且病毒基因功能似乎与这种干扰现象有关。
In this investigation the sensitivity of vaccinia virus to interferon (IFN) has been examined in cultured cells. In a variety of mouse and human cells of different origins vaccinia virus functions (RNA, protein, and virus yields) were found to be relatively resistant to IFN. In these systems, the levels of the IFN-mediated enzyme activities (2–5A synthetase and protein kinase) were severely impaired by the virus. This virus-mediated inhibitory effect developed with time after infection and was dependent on viral protein synthesis. Mixed infections between vaccinia virus and viruses (VSV or polio) which are sensitive to IFN showed that both protein synthesis and virus yields were not inhibited. These findings show that vaccinia virus can overcome the antiviral action of IFN and that viral gene functions appear to be involved in this interference phenomenon.