Metal-free O-H/C-H difunctionalization of phenols by o-hydroxyarylsulfonium salts in water.
Metal-free O-H/C-H difunctionalization of phenols by o-hydroxyarylsulfonium salts in water.
复制标题
水中邻羟基芳基锍盐对苯酚的无金属 O-H/C-H 双官能化
DOI：
10.1039/c6sc04504a
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发表时间：
2017-02-01
期刊：
影响因子：
8.4
通讯作者：
Huang S
中科院分区：
文献类型：
--
作者：
Chen D;Feng Q;Yang Y;Cai XM;Wang F;Huang S
在温和的绿色条件下，通过将C-H键和O-H键直接官能化为C-S键和C-O键，构建了多官能芳环。本文报道了一种环境友好的亚砜与苯酚的C-H/O-H双官能化反应。反应过程是由亲电芳香取代和随后的选择性芳基或烷基迁移介导的，涉及具有广泛底物范围的C-S和C-O键形成。
Polyfunctional aromatic rings have been constructed by direct functionalization of C–H and O–H bonds to C–S and C–O bonds under mild and green conditions. An environmentally benign method for C–H/O–H difunctionalization of phenols with sulfoxides under mild conditions has been developed. The reaction process is mediated by an electrophilic aromatic substitution and subsequent selective aryl or alkyl migration, involving C–S and C–O bond formations with broad substrate scope.