Inhibition of the growth of lymphoid tumours in syngeneic athymic (nude) mice
Inhibition of the growth of lymphoid tumours in syngeneic athymic (nude) mice
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抑制同基因无胸腺（裸）小鼠淋巴肿瘤的生长
DOI：
10.1002/ijc.2910200122
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发表时间：
1977
影响因子：
6.4
通讯作者：
R. Burton
中科院分区：
文献类型：
--
作者：
N. Warner;M. Woodruff;R. Burton
对 BALB/c、BALB/c.nu/+（杂合裸鼠）和 BALB/c.nu（纯合裸鼠）中许多 BALB/c 肿瘤生长的比较表明，大多数 BALB/c 淋巴肿瘤在 BALB/c.nu 小鼠中的生长速度显着降低。然而，测试的三种非淋巴 BALB/c 肿瘤（癌和肉瘤）和少数淋巴肿瘤在 BALB/c.nu 小鼠中生长得一样好，甚至更好。此外，迄今为止无一例外地，从肿瘤细胞系对同基因裸鼠脾细胞体外裂解的敏感性与其在同基因裸鼠体内生长之间的比较中发现了相关性。与同基因正常小鼠相比，只有那些体外裂解的淋巴肿瘤细胞系在同基因裸鼠中显示出生长速率降低。对体外裂解具有抗性的淋巴和非淋巴肿瘤细胞系在同系裸鼠中并未表现出体内生长速率降低。在使用前对裸鼠进行照射可以部分消除体内和体外效应，这表明对淋巴肿瘤的辐射敏感的非T细胞监测正在裸鼠中进行。虽然抗原的身份仍然未知，但该现象的特异性表明涉及 C 型 RNA 致癌病毒确定的抗原。
A comparison of the growth of a number of BALB/c tumours in BALB/c, BALB/c.nu/+ (heterozygous nude) and BALB/c.nu (homozygous) nude mice has shown that a majority of BALB/c lymphoid tumours grow at a significantly reduced rate in BALB/c.nu mice. The three non‐lymphoid BALB/c tumours (carcinomas and sarcomas) tested and a minority of lymphoid tumours, however, grew as well, or better, in the BALB/c.nu mice. Furthermore a correlation, without exception to date, has emerged from a comparison between the susceptibility of a tumour cell line to in vitro lysis by spleen cells from syngeneic nude mice and its growth in vivo in syngeneic nude mice. Only those lymphoid tumour cell lines lysed in vitro show the reduced growth rate in syngeneic nude as compared to syngeneic normal mice. Tumour cell lines, both lymphoid and non‐lymphoid, which are resistant to in vitro lysis do not show the reduced in vivo growth rate in syngeneic nude mice. Both the in vivo and in vitro effect can be partially abolished by irradiating the nude mice prior to use, suggesting that a radiation‐sensitive non‐T‐cell surveillance of lymphoid tumours is operating in nude mice. While the identity of the antigens is still unknown, the specificity of the phenomena suggest that C‐type RNA oncogenic viral determined antigens are involved.