Cellular bioterrorism:: how Brucella corrupts macrophage physiology to promote invasion and proliferation
Cellular bioterrorism:: how Brucella corrupts macrophage physiology to promote invasion and proliferation
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DOI：
10.1016/j.clim.2004.07.010
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发表时间：
2005-03-01
影响因子：
8.6
通讯作者：
Gross, A
中科院分区：
文献类型：
--
作者：
de Bagues, MPJ;Dudal, S;Gross, A
布鲁氏菌病是一种由布鲁氏菌属细胞内细菌引起的世界性人兽共患传染病。毒力因子在布鲁氏菌感染和巨噬细胞增殖中起重要作用。布鲁氏菌通过脂筏微区进入巨噬细胞，避免吞噬溶酶体融合，并抑制TNF-α分泌和凋亡。此外，布鲁氏菌可通过其LPS或通过激活cAMP/PKA途径影响宿主细胞对其有利的反应来干扰巨噬细胞中的杀菌活性。迄今为止，在定义和理解用于巨噬细胞颠覆的布鲁氏菌毒力因子方面已经取得了一些进展，但需要进一步研究以充分解释毒力和持久性。(C)2004年爱思唯尔公司All rights reserved.
Brucellosis is a worldwide human zoonosis caused by intracellular bacteria of the genus Brucella. Virulence factors play an important role in allowing Brucella infection and proliferation within macrophages. Brucella enters macrophages through lipid raft microdomains, avoids phagolysosome fusion, and inhibits TNF-alpha secretion and apoptosis. Furthermore, Brucella can perturb bactericidal activity in macrophages by influencing the host cell response to its advantage through its LPS or by activating the cAMP/PKA pathway. To date, small steps have been taken in defining and understanding the virulence factors of Brucella used in macrophage subversion, but further investigation is required to fully explain virulence and persistence. (C) 2004 Elsevier Inc. All rights reserved.